The tubulin vinca domain is the target of widely different microtubule inhibitors that interfere with the binding of vinblastine. Although all these ligands inhibit the hydrolysis of GTP, they affect nucleotide exchange to variable extents. The structures of two vinca domain antimitotic peptides--phomopsin A and soblidotin (a dolastatin 10 analogue)--bound to tubulin in a complex with a stathmi...

The hydroalcoholic extracts of dried ligulate florets of Calendula officinalis L., dried leaves of Plantago major L., and dried aerial parts of Vinca major L. were prepared and used as the main active ingredients of two types of anti-anorectal disease ointments and suppositories. Benzocaine was used in one of the formulations, while a mixture of belladonna dry extract and ephedrine sulfate ...

Although coral reef health across the globe is declining as a result of anthropogenic impacts, relatively little is known of how environmental variability influences reef organisms other than corals and fish. Sponges are an important component of coral reef fauna that perform many important functional roles and changes in their abundance and diversity as a result of environmental change has the...

We have isolated fifty-two endophytic fungi (AA-CRL-1 to AA-CRL52) from the leaves of Catharanthus roseus plants collected from different parts of Pune (Maharashtra, India). These endophytic fungi represented different genera and were screened for vinca alkaloids production using TLC and ESI-MS analysis. Out of the 52 endophytic fungal cultures screened, the endophytic culture AA-CRL-20 was fou...

The paper presents a service composition language called VINCA, which differs from many existing ones in its emphasis on enabling business users to visually “program” from business view-point their personalized applications on the basis of Web-based services. VINCA embodies an integrated approach to mediating between diverse, rapidly changing user requirements and composites of individual servi...

The germination of three cerrado herbaceous species: Bidens gardneri, Vernonia herbacea (Asteraceae) and Psychotria barbiflora (Rubiaceae) was studied using seeds stored in cerrado soil and in refrigerator at 4°C. The field experiment was carried out at a preserved area of cerrado, the Reserva Biológica e Estação Experimental de Mogi-Guaçu, State of São Paulo, Brazil. The soil was collected in ...

Cancer chemotherapeutic drugs acts in different manner to kill malignant cells. Most of the anticancer available clinical practice treat cancer patients, are natural products including whole plant extract, crude extracts, isolated constituents, –based drug formulations etc. These compounds have been a basis for development several against cancer. Agents such as topotecan, taxol, vinca alkaloids...

Chemotherapy induced peripheral neuropathy (CIPN), a side effect of many anti-cancer drugs including the vinca alkaloids, is characterized by a severe pain syndrome that compromises treatment in many patients. Currently there are no effective treatments for this pain syndrome except for the reduction of anti-cancer drug dose. Existing data supports the model that the pain associated with CIPN i...

The suitability of neurons of the freshwater snail Lymnaea stagnalis as a test system for the neurotoxic side effects of antitumour Vinca alkaloids has been investigated, by studying the process of paracrystal induction by Vinca antitumour agents. Three Vinca alkaloids have been compared: the natural vinblastine and vincristine and the semisynthetic vindesine. They appear to induce two types of...