Measurements of villus height, villus area, together with counts of epithelial cells in individual villi, were performed on endoscopic duodenal biopsies from five groups of patients: controls, ulcer-associated duodenitis, mild and severe non-specific (non-ulcerative) duodenitis, cimetidine healed ulcer-associated duodenitis and cimetidine healed non-specific duodenitis. The objectives of the st...

Glutamine, the primary metabolic fuel for the mammalian small intestinal enterocytes, is primarily assimilated by Na-amino acid cotransporters. Although Na-solute cotransport has been shown to exist in the brush border membrane (BBM) of the absorptive villus cells, the identity of Na-glutamine cotransport in rabbit small intestinal villus cells was unknown. Na-dependent glutamine uptake is pres...

M I T O T I C expansion of the mucosa coupled with contraction of intrinsic longitudinal and circular muscle fibers produces previllous ridges on the luminal surface of the embryonic chick duodenum by the thirteenth day of incubation. Subsequently, remodelling by periodic indentation of the mucosal surface yields primitive villi which expand and elongate to form the tall, finger-like projection...

Clostridium perfringens enterotoxin (CPE) causes the symptoms of a very common food poisoning. To assess whether CPE-induced cytotoxicity is necessary for enterotoxicity, a rabbit ileal loop model was used to compare the in vivo effects of native CPE or recombinant CPE (rCPE), both of which are cytotoxic, with those of the noncytotoxic rCPE variants rCPE D48A and rCPE(168-319). Both CPE and rCP...

The small intestines of hatching chicks undergo rapid developmental changes in the immediate post-hatch period when the birds are making the transition from endogenous nutrient supply from yolk to dependence on exogenous feed. This transition usually only begins 48 h or more after hatching, owing to logistical considerations of production. The effects of fasting for 48 h at different times duri...

Rat small intestinal epithelial cell lines have been established in vitro and subcultured serially for periods up to 6 mo. These cells have an epithelioid morphology, grow as monolayers of closely opposed polygonal cells, and during the logarithmic phase of growth have a population doubling time of 19--22 h. Ultrastructural studies revealed the presence of microvilli, tight junctions, an extens...

Nutrient absorption in the small intestine cannot occur until molecules are presented to the epithelial cells that line intestinal villi, finger-like protrusions under enteric control. Using a two-dimensional multiscale lattice Boltzmann model of a lid-driven cavity flow with 'villi' at the lower surface, we analyse the hypothesis that muscle-induced oscillatory motions of the villi generate a ...

the effects of dietary supplementation of grape seed extract (gse) and vitamin c on carcass characteristics, gut morphology and ileal microflora in broiler chickens exposed to chronic heat stress were examined. experimental diets included a control diet (without additive), 3 levels of gse (150, 300, 450 mg/kg of diet), and vitamin c (300 mg/kg of diet). each of the five diets was fed to 5 repli...

a total of 448 ross 308 seven-day old male broiler chicks were assigned to seven treatments with four replicates, each containing 16 chicks, to determine effects of physical sizes and rate of dietary inclusion of clinoptilolite. the chicks fed diet containing clinoptilolite at 1.5% and particle size of 0.4-0.8 mm showed significantly higher body weight gain than the control group that did not r...