The molecular vibration-activity relationship in the receptor-ligand interaction of adenosine receptors was investigated by structure similarity, molecular vibration, and hierarchical clustering in a dataset of 46 ligands of adenosine receptors. The resulting dendrogram was compared with those of another kind of fingerprint or descriptor. The dendrogram result produced by corralled intensity of...

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Results: The peak vibration frequency was about 150 Hz irrespective of vibration intensity, which would effectively activate fast adapting type II (FAII) cutaneous mechanical receptors. The two-point discrimination threshold measured at the third pad of the index finger decreased significantly when a near-threshold vibrotactile stimulus was applied to the dorsal hand, a response termed stochast...

Haptic gloves allow virtual reality environments and video games to increase their inmersion levels by providing vibrational feedback while the user manipulates virtual objects. The present work describes the design of a haptic glove capable of providing vibratory stimuli with variable feedback based on the proposal of using the physical interaction between virtual objects and the user’s hand a...

Prolonged exposure to vibration has been associated with the development of handarm vibration syndrome (HAVS). While vibration is known to have adverse physiological effects on the tissues of the human hand, it is still unclear how these physiological effects are influenced by factors such as tissue thickness or vibration intensity, frequency, and duration. Understanding the response of the han...