BACKGROUND The early repolarization (ER) pattern on ECG is associated with an increased risk of idiopathic ventricular fibrillation (ID-VF). Hypothermia is known to result in similar electrocardiographic changes. In this retrospective cohort study, we examine the impact of therapeutic hypothermia on ER in survivors of cardiac arrest attributed to ID-VF and draw comparisons with a control group ...

The cellular events during the initiation and maintenance of ventricular fibrillation (VF) are poorly understood. We developed a nonischemic, isolated, perfused rabbit Langendorff preparation in which sustained VF could be induced by alternating current (AC) and which allowed changes in perfusate composition. We also used Na+-K+ pump inhibition (10 ,uM ouabain or K'-free perfusate) to induce VF...

Cardiac alternans, a beat-to-beat alternation of cardiac electrical dynamics, and ventricular tachycardia, generally associated with a spiral wave of electrical activity, have been identified as frequent precursors of the life-threatening spatiotemporally chaotic electrical state of ventricular fibrillation (VF). Schemes for the elimination of alternans and the stabilization of spiral waves thr...

OBJECTIVES To develop an appropriate method of assessing visual field (VF) loss which reflects its functional consequences, this study aims to determine which method(s) of assessing VF best reflect mobility difficulty. SETTING This cross-sectional observational study took place within a single primary care setting. Participants attended a single session at a University Eye Clinic, Cambridge, ...

BACKGROUND Video feedback (VF) interventions effectively reduce social anxiety symptoms and negative self-perception, particularly when they are preceded by cognitive preparation (CP) and followed by cognitive review. AIMS In the current study, we re-examined data from a study on the efficacy of a novel VF intervention for individuals high in social anxiety to test the hypothesis that physica...

BACKGROUND Much of the research performed studying the mechanism of ventricular fibrillation (VF) has been in normal ventricles rather than under a pathological condition predisposing to VF. We hypothesized that different ventricular substrates would alter the mechanism and characteristics of VF. METHODS AND RESULTS Three groups of dogs were studied: (1) control (n=8), (2) pacing-induced cong...

Abbreviation of the action potential duration and/or effective refractory period (ERP) is thought to decrease the cycle length of reentrant arrhythmias. Verapamil, however, paradoxically converts ventricular fibrillation (VF) to ventricular tachycardia (VT), despite reducing the ERP. This mechanism remains unclear. We hypothesize that the size and the dynamics of the core of rotating waves, in ...

This paper presents a new nonlinear method to analyze ventricular arrhythmia(VA) and sinus rhythms(SR). The problem is introduced from the discussion of Fractal Random Walk characteristics of ECG signal. Further, the fractal analysis is used to distinguish ventricular flutter(VFL), ventricular fibrillation(VF), ventricular tachycardia(VT)) and sinus rhythms(SR) from the raw electrocardiogram(EC...

BACKGROUND After defibrillation of initial ventricular fibrillation (VF), it is crucial to prevent refibrillation to ensure successful resuscitation outcomes. Inability of the late Na+ current to inactivate leads to intracellular Ca2+ dysregulation and arrhythmias. Our aim was to determine the effects of ranolazine and GS-967, inhibitors of the late Na+ current, on ventricular refibrillation. ...