Ionizing radiation exposure is associated with activation of certain immediate-early genes that function as transcription factors. These include members of jun or fos and early growth response (EGR) gene families. In particular, the functional role of EGR-1 in radiation-induced signaling is pivotal since the promoter of EGR-1 contains radiation inducible CArG DNA sequences. The Egr-1 gene belon...

Vehicle Emission is one of the main causes of environmental damage. Vehicle engines produce carbon dioxide (CO2), hydrocarbon (HC), Nitrogen oxides (NOx) and many other harmful substances. An investigation was conducted using a compression-ignition engine fuelled with different ratios of blends of diesel and biodiesel at different EGR rates. The effects of different ratios of fuel blends and EG...

Necrosis is commonly found in the core region of solid tumours due to metabolic stress such as hypoxia and glucose deprivation (GD) resulting from insufficient vascularization. Necrosis promotes tumour growth and development by releasing the tumour-promoting cytokine high mobility group box 1 (HMGB1); however, the molecular mechanism underlying necrotic cell death remains largely unknown. In th...

This paper describes a low-pressure exhaust gas recirculation (LP-EGR) mass flow rate estimation method and a robust air mass fraction observer for a Diesel engine with dualloop EGR system. Both observers operate simultaneously eliminating the need for pressure measurement upstream the LP-EGR valve. A sliding mode observer is designed to estimate the LP-EGR mass flow rate using the standard sen...

Enteropathogenic Escherichia coli (EPEC) is an extracellular bacterial pathogen that infects the human intestinal epithelium and is a major cause of infantile diarrhea in developing countries. EPEC belongs to the group of attaching and effacing (A/E) pathogens. It uses a type III secretion system to deliver proteins into the host cell that mediate signal transduction events in host cells. We us...

Abstract The mode of exhaust gas recirculation (EGR) and the flow recirculated greatly impact heat recovery mechanical turbo-compound. A matching turbo-compound diesel engine is established with GT-power software to study effect EGR rate on it, working performance under high-pressure low-pressure also studied. results show that compared original engine, effective thermal efficiency matched has ...

methanol as a biofuel is an environmental friendly substitute to pure diesel and can be obtained from biomasses. use of biofuels such as methanol for combustion process is associated with positive environmental impacts. using pure methanol or blended with diesel fuel in automotive has been proposed by researchers. in this paper, methanol was injected into combustion chamber of a ism 370 hd dies...

Changes in extracellular glucose levels regulate the expression of the immediate-early response gene and zinc finger transcription factor early growth response-1 (Egr-1) in insulin-producing pancreatic beta-cells, but key target genes of Egr-1 in the endocrine pancreas have not been identified. We found that overexpression of Egr-1 in clonal (INS-1) beta-cells increased transcriptional activati...

Early growth-response factor 1 (Egr-1) is a zinc-finger transcription factor that plays a regulatory role in the expression of many genes important for inflammation. Whether Egr-1 is involved in IgEdependent mast-cell activation was investigated. We demonstrated that IgE and antigen (TNP) stimulation induced a rapid expression of Egr-1 mRNA in mouse bone marrow–derived mast cells (BMMCs). As ea...