BACKGROUND The purpose of this study was to evaluate the effects of benzalkonium (BAK)-free travoprost monotherapy administered for 3 years on intraocular pressure and visual field performance. METHODS The intraocular pressure of 76 patients with normal tension glaucoma was monitored every 1-3 months. A Humphrey visual field test was performed every 6 months after treatment and compared with ...

The chemical variation of clinopyroxene phenocrysts from the trachybasaltic lavas of Etna volcano is described. The phenocrysts show a limited, but distinct trend in chemical variation from calcic-augite in the hawaiites to augite in the benmoreites. The trend of this variation is unusual, being one of Mg-enrichment with differentiation of the magma. Ca shows a steady decrease in the clinopyrox...

climatic parameters in time and space scales of change are for many reasons of changes and how they should be based on observations using a statistical method to be determined. analysis of the most widely used statistical methods that assess potential climate change on hydrological time series, such series of precipitation, temperature and flow rate used. this study of 11 synoptic,rain gage and...

Identifying temporal variation in hospitalization rates may provide insights about disease patterns and thereby inform research, policy, and clinical care. However, the majority of medical conditions have not been studied for their potential seasonal variation. The objective of this study was to apply a data-driven approach to characterize temporal variation in condition-specific hospitalizatio...

Background: Betweenand within-person variation in DNA methylation levels are important parameters to be considered in epigenome-wide association studies. Temporal change is one source of within-person variation in DNA methylation that has been linked to aging and disease. Methods: We analyzed CpG-site–specific intraindividual variation and short-term temporal trend in leukocyte DNA methylation ...

A theoretical study on the effects of a moderate amount of sulfur when used as substituent impurity in place of oxygen in zinc oxide at its crystal form using Density Functional Theory (DFT). S-substituent amounts in percent go from 0.1% up to 1.0% and we analyze modifications in the crystal properties such as lattice characteristics, total energy, and gap energy. Lattice parameter c increased ...

BACKGROUND Between- and within-person variation in DNA methylation levels are important parameters to be considered in epigenome-wide association studies. Temporal change is one source of within-person variation in DNA methylation that has been linked to aging and disease. METHODS We analyzed CpG-site-specific intraindividual variation and short-term temporal trend in leukocyte DNA methylatio...

Structural breaks and switching processes are known to induce apparent long memory in a time series. Here we show that any significant time variation in the mean renders the sample correlogram (and related spectral estimates) inconsistent. In particular, smooth time variation in the mean—i.e., even a weak trend, either stochastic or deterministic—induces apparent long memory. This apparent long...

BACKGROUND The mortality rates of older people changes with the seasons. However, it has not been properly investigated whether the seasons affect medical care expenditure (MCE) and institutionalization. Seasonal variation in MCE is plausible, as MCE rises exponentially before death. It is therefore important to investigate the impact of the seasons on MCE both mediated and unmediated by mortal...