The pharmacokinetics and urinary excretion following single intramuscular administration of levofloxacin at a dose of 4 mg/kg was investigated in seven male cross bred calves. Appreciable plasma concentration of levofloxacin (0.38+/-0.06 microgram/ml) was detected at 1 min after injection and the peak plasma level of 3.07+/-0.08 microgram/ml was observed at 1 h. The drug level above MIC90 in pl...

PURPOSE Antitumor clinical activity has been demonstrated for the MDM2 antagonist RG7112, but patient tolerability for the necessary daily dosing was poor. Here, utilizing RG7388, a second-generation nutlin with superior selectivity and potency, we determine the feasibility of intermittent dosing to guide the selection of initial phase I scheduling regimens. EXPERIMENTAL DESIGN A pharmacokine...

Die Veränderungen der Warenströme und Neuerungen der Rechtsnormen im Bereich der Lebensmittelsicherheit müssen einen adäquaten Niederschlag in der Gestaltung und Einführung von IT-basierten Informationsund Kommunikationssystemen finden. Zur Förderung der Akzeptanz solcher Systeme müssen zudem Determinanten einer vertrauensbildenden Kommunikation berücksichtigt werden. Ziel des Beitrags ist es, ...

Die Veränderungen der Warenströme und Neuerungen der Rechtsnormen im Bereich der Lebensmittelsicherheit müssen einen adäquaten Niederschlag in der Gestaltung und Einführung von IT-basierten Informationsund Kommunikationssystemen finden. Zur Förderung der Akzeptanz solcher Systeme müssen zudem Determinanten einer vertrauensbildenden Kommunikation berücksichtigt werden. Ziel des Beitrags ist es, ...

The budgetary implications of an aging population in the OECD are often considered dire. This study argues that this need not be the case provided that older educated workers are more innovative than their younger counterparts, and that workers with tertiary education stay in the labor force until their 60s. Using a panel of 21 OECD countries over the period 1870-2009, this paper estimates the ...

Extended-interval dosing of gentamicin has several advantages over conventional multiple-daily dosing for the treatment of sepsis. The study was conducted to evaluate the pharmacokinetics of gentamicin for the treatment of neonatal sepsis in predetermined doses at 24- or 48-hour intervals, according to weight category, and to develop a simplified protocol for use in peripheral healthcare settin...

The pharmacokinetics of enrofl oxacin (ENR) were investigated after intravenous (i/v) administration in inbred (n = 10) and outbred (n = 10) healthy rabbits. After i/v ENR injection the elimination half-life (t1/2β), total body clearance (ClB) and the area under the concentration vs. time curve (AUC) in inbred rabbits were 1.51 h, 28.35 ± 1.51 ml/kg/min and 3.01 ± 0.16 μg.h/ml, respectively. Th...

The purpose of this study was to evaluate the potential of micelle to change the pharmacokinetics of quercetin (QUT), with a primary goal of enhancing its oral bioavailability. QUT-loaded methoxy poly(ethylene glycol)-b-poly(L-lactic acid) micelle (QUT-loaded MPEG-b-PLLA micelle) was prepared by a thin-film hydration method, resulting in a particle size of 88.5 nm. A liquid chromatography tande...

Abstrakt: Bei der Auswahl einer geeigneter Migrationsstrategie müssen u.a. die Kosten berücksichtigt werden. Das macht es erforderlich den Aufwand für jedes Alternativ zu schätzen und zu vergleichen. In dem Projekt, das hier geschildert wird gab es drei Alternative, den alten Code direkt 1:1 in Java konvertieren, den alten Code erst zu sanieren und dann in Java transformieren, und den Code komp...

Background: GAI and MPSIIIB are two rare genetic disorders caused by pathogenic variants in two different genes. Here, we report a coexistence of these two different rare disorders in an individual. Methods: A four-year-old Iranian boy born to first-cousin parents suspected to have MPSIIIB and/or GAI was investigated in this study. Targeted genomic enrichment and NGS were used to examine genes ...