نتایج جستجو برای: vancomycin

تعداد نتایج: 13441  

Journal: :Journal of infection in developing countries 2015
Sujintana Wongthong Karnjana Dutchanutouch Viladda Namsaengkang Aroonwadee Chanawong Chotechana Wilailuckana Aroonlug Lulitanond

INTRODUCTION Detection of heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) is currently problematic. Although the population analysis profile with area under the curve (PAP-AUC) is the gold standard for detecting hVISA strains, this method is time consuming. This study aimed to induce vancomycin non-susceptible Staphylococcus aureus isolates in methicillin-resistant S. aureus...

2012
Tamar Lasky Jay Greenspan Frank R. Ernst Liliana Gonzalez

BACKGROUND Recommendations to prevent the spread of vancomycin resistance have been in place since 1995 and include guidelines for inpatient pediatric use of vancomycin. The emergence of large databases allows us to describe variation in pediatric vancomycin across hospitals. We analyzed a database with hospitalizations for children under 18 at 421 hospitals in 2008. METHODOLOGY/PRINCIPAL FIN...

Journal: :Antimicrobial agents and chemotherapy 1991
M A Smith J A Sorenson C Smith M Miller M Borenstein

Intravitreal corticosteroids in the treatment of bacterial endophthalmitis remain controversial. We utilized an experimental rabbit model of methicillin-resistant Staphylococcus epidermidis endophthalmitis (i) to calculate the intravitreal vancomycin concentration in rabbit eyes receiving intravitreal vancomycin alone or in combination with intravitreal dexamethasone and (ii) to determine wheth...

Journal: :Antimicrobial agents and chemotherapy 1999
J R Aeschlimann E Hershberger M J Rybak

Methicillin-resistant Staphylococcus aureus strains with decreased vancomycin susceptibility have been isolated from patients in the United States and Japan. The impact of decreased vancomycin susceptibility on the drug's pharmacodynamic parameters has not been addressed. We studied the activity of vancomycin against three clinical strains of vancomycin intermediate-susceptible Staphylococcus a...

Amineh Sadat Tajani Asma Mahmoudi, Bahman Khameneh, Bizhan Malaekeh-Nikouei, Majid Abrishami Mehrdad Motamed Shariati Mojtaba Abrishami,

Objective(s): The in vivo efficacy of nanoliposomal formulation of vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) assessed.Materials and Methods: Nanoliposomal formulations were prepared and characterized. The in vivo study was carried out on rabbits which received liquid culture medium containing MRSA under anesth...

2009
Oskar Nilsson Christina Greko Björn Bengtsson

BACKGROUND Vancomycin resistant enterococci are a frequent cause of nosocomial infections and their presence among farm animals is unwanted. Using media supplemented with vancomycin an increase in the proportion of samples from Swedish broilers positive for vancomycin resistant enterococci has been detected. The situation at farm level is largely unknown. The aims of this study were to obtain b...

2015
Blanca Humanes Juan Carlos Jado Sonia Camaño Virginia López-Parra Ana María Torres Luís Antonio Álvarez-Sala Emilia Cercenado Alberto Tejedor Alberto Lázaro

Vancomycin is a very effective antibiotic for treatment of severe infections. However, its use in clinical practice is limited by nephrotoxicity. Cilastatin is a dehydropeptidase I inhibitor that acts on the brush border membrane of the proximal tubule to prevent accumulation of imipenem and toxicity. The aim of this study was to investigate the potential protective effect of cilastatin on vanc...

2014
Sepideh Elyasi Hossein Khalili Simin Dashti-Khavidaki Hamid Emadi-Koochak Amirhooshang Mohammadpour Alireza Abdollahi

Vancomycin susceptibility of methicillin-resistant Staphylococcus aureus has been changed over time and its average minimum inhibitory concentration increased from 1.5 to 1.75 mg/L.A recently published guideline by the American Society of Health Pharmacist recommended a daily dose of 15-20 mg/Kg every 8 to 12 hours of vancomycin to achieve a trough concentration between 15-20 mg/L for treatment...

2018
Feng Wang Hongyu Zhou Olatunde P. Olademehin Sung Joon Kim Peng Tao

Vancomycin is a glycopeptide antibiotic used for the treatment of serious infections by Gram-positive pathogens. Vancomycin inhibits cell wall biosynthesis by targeting the d-Ala-d-Ala terminus of peptidoglycan (PG). The highly cross-linked heptapeptide aglycon structure of vancomycin is the d-Ala-d-Ala binding site. The first residue of vancomycin is N-methyl-leucine, which is crucial for the ...

Journal: :Antimicrobial agents and chemotherapy 1999
H Shuto M Sueyasu S Otsuki T Hara Y Tsuruta Y Kataoka R Oishi

The intravenous injection of vancomycin sometimes causes anaphylactoid reactions, in which histamine release may play a major role. These reactions are more frequently manifested when vancomycin is injected into anesthetized patients. We examined the vancomycin-induced histamine release and the interaction of vancomycin with muscle relaxants or opioid in rats. In an in vitro study with rat peri...

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