ABstRAct The technology acceptance model (TAM) is a popular model for the prediction of information systems acceptance behaviors, defining a causal linkage between beliefs, attitudes, intentions, and the usage of information technologies. Since its inception, numerous studies have utilized the TAM, providing empirical support for the model in both traditional and Internet-based computing settin...

We describe an integrated framework for system-on-chip (SOC) test automation. Our framework is based on a new test access mechanism (TAM) architecture consisting of flexible-width test buses that can fork and merge between cores. Test wrapper and TAM cooptimization for this architecture is performed by representing core tests using rectangles and by employing a novel rectangle packing algorithm...

a successful e-crm strategy and implementation should be able to demonstrate a shift in the number of interactions from higher cost channels to lower cost electronic channels. combining this with the ability to demonstrate either sustained or improved relationship strength levels will provide a good overall indicator of the value of a company’s e-crm activities. highly effective e-crm comes whe...

Tumor-associated macrophages (TAMs), the most abundant immunosuppressive cells in the tumor microenvironment, originate from blood monocytes and exhibit an IL-10(high)IL-12(low) M2 profile. The factors involved in TAM generation remain unidentified. We identify here leukemia inhibitory factor (LIF) and IL-6 as tumor microenvironmental factors that can promote TAM generation. Ovarian cancer asci...

The effect of tamoxifen (TAM) on human endometrii carci noma was investigated in nude mice bearing an estrogen recep tor-positive or estrogen receptor-negative tumor. The receptornegative tumor grew rapidly, and the rates of tumor growth of 17/3-estradiol or TAM-treated animals were identical to the rate of controls. The estradici receptor and progesterone receptor (PR) concentrations in the tu...

Background Adjuvant tamoxifen therapy approximately halves the risk of estrogen receptor-positive (ER+) breast cancer recurrence, but many women do not respond to therapy. Observational studies nested in clinical trial populations suggest that overexpression or nuclear localization of p21-activated kinase 1 (Pak1) in primary tumors predicts tamoxifen failure. Material and methods We measured th...

BACKGROUND We studied the effect of adjuvant anthracycline-based chemotherapy in postmenopausal patients with resected early breast cancer treated with adjuvant tamoxifen. PATIENTS AND METHODS The trial included 835 patients with either axillary lymph node involvement, or tumors with histological grade II or III. They were randomized after local surgery to receive either tamoxifen (TAM group)...

Purpose – The available literature suggest that the research on radio frequency identification (RFID)-related issues is largely concentrated on technical, organizational and implementation aspects, and comparatively lesser attention has been invested in understanding the use aspect of such library management systems. The purpose of this paper is to gain an understanding into the factors that in...

The cytotoxic effect of tamoxifen (TAM) was investigated in the T-289 melanoma cell line, as well as the 289 DDP3 cisplatin (DDP)-resistant and the 289 TAM6 TAM-resistant variant melanoma cell lines to determine the effect of drug resistance on synergy. T-289 melanoma cells were made DDP or TAM resistant through chronic exposure to increasing concentrations of the respective drugs. Whereas DDP ...