During branch and bound search in deterministic global optimization, adaptive subdivision is used to produce subregions x, which are then eliminated, shown to contain an optimal point, reduced in size, or further subdivided. The various techniques used to reduce or eliminate a subregion x determine the efficiency and practicality of the algorithm. Ryoo and Sahinidis have proposed a “probing” te...

Clonidine hydrochloride is an antihypertensive agent used for migraine prophylaxis, attention deficit hyperactivity disorder, menopausal flushing and Tourette syndrome. The quantity of the active substance in pharmaceutical preparations must be within specific limits, in agreement with the respective label claim. Therefore, the aim of this study was to establish the conditions for two spectroph...

Clonidine hydrochloride is an antihypertensive agent used for migraine prophylaxis, attention deficit hyperactivity disorder, menopausal flushing and Tourette syndrome. The quantity of the active substance in pharmaceutical preparations must be within specific limits, in agreement with the respective label claim. Therefore, the aim of this study was to establish the conditions for two spectroph...