To the Editor—Cytomegalovirus (CMV) disease is a common pathogen and represents a difficult clinical problem in transplant recipients. CMV-naive patients receiving a CMV-positive allograft may experience complications, such as retinitis, gastritis, colitis, and pneumonitis, which may force clinicians to reduce immunosuppressive agents, thereby risking rejection. However oral agents, such as val...

OBJECTIVES To determine whether valganciclovir 450 mg every 48 h for cytomegalovirus (CMV) prophylaxis provides appropriate ganciclovir exposure in solid organ transplant recipients during continuous renal replacement therapy (CRRT). PATIENTS AND METHODS Ganciclovir pharmacokinetics was intensively studied in two lung transplant recipients under valganciclovir 450 mg every 48 h over one dosin...

BACKGROUND Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) is a rare and severe adverse drug reaction with an associated mortality of 10-20%. Clinical worsening despite discontinuation of the culprit drug is considered a characteristic feature of DIHS/DRESS. Besides the early recognition of the syndrome and discontinuation of its causati...

BACKGROUND In a randomized study, we observed a higher incidence of biopsy-proven acute rejection with pre-emptive valganciclovir therapy as compared with valacyclovir prophylaxis for prevention of cytomegalovirus (CMV) disease after renal transplantation (RTx). Persistence of the virus within the allograft could stimulate the alloimmune response. The aim of our study was to evaluate intragraft...

10.2217/14750708.2.3.333 © 2 part of Cytomegalovirus (CMV) continues to be an important cause of significant disease in various groups of immunocompromised hosts, including organ and hematopoietic stem cell transplant recipients and AIDS patients. Therapeutic and preventative strategies have been used in these patients to improve overall outcomes. Ganciclovir has traditionally been the first-li...

We suggest ganciclovir by IV administration be the treatment of choice for moderate-severe Cytomegalovirus (CMV) disease and patients with gastrointestinal involvement where drug absorption may be impaired. Mild CMV disease in adults may be treated with either oral valganciclovir or IV ganciclovir (Level II evidence, single study). Drug dose should be reduced in patients with renal impairment. ...

cytomegalovirus (cmv) infection can cause colitis which is usually manifested with fever, weight loss, anorexia and abdominal pain.watery diarrhea can be the only manifestation. cmv colitis usually can not be diagnosed according to the clinical findings. moreover, endoscopic appearance can exactly mimic pseudo-membranous colitis. here by, we are presenting a patient with fever and watery diarrh...