Major depressive disorder is a common global disease that causes a significant societal burden. Most interventional studies of depression provide a limited assessment of the interventions on mortality and suicide risks. This study utilizes data from an observational registry of patients with major depressive disorder to determine the impact of intervention (vagus nerve stimulation or standard p...

AbsractA rare variant of ansa cervicalis was discovered during dissection of the neck in amale cadaver. The superior root of the Ansa cervicalis was formed by the C1 ventralramus. It accompanied with the vagus nerve in place of the hypoglossal nerve and descendedinto the carotid sheath with it. Moreover the C1 ventral ramus formed fromthe sheath and joined the inferior root from C2 and C3 ventr...

Hosoi, Toru, Yasunobu Okuma, and Yasuyuki Nomura. Electrical stimulation of afferent vagus nerve induces IL-1b expression in the brain and activates HPA axis. Am J Physiol Regulatory Integrative Comp Physiol 279: R141–R147, 2000.—Possible roles of the afferent vagus nerve in regulation of interleukin (IL)-1b expression in the brain and hypothalamic-pituitary-adrenal (HPA) axis were examined in ...

Activation of the parasympathetic pathway leads to negative chronotropic, dromotropic, and inotropic changes of heart function. The ability to selectively stimulate certain superficial compartments of peripheral nerves has been demonstrated previously. The aim of the present study was to find a clinically acceptable selective biphasic vagus nerve stimulation technique, which could allow gradual...

We determined the extent of convergence of preganglionic fibers from the right and left vagus nerves on postganglionic neurons that supply the sinoatrial node in chloralose-anesthetized dogs. We administered hemicholinium-3 and stimulated the right vagus nerve at a high frequency to deplete acetylcholine from the postganglionic parasympathetic neurons supplied by that nerve. We compared the eff...

The vagus nerve is a major component of the autonomic nervous system, has an important role in the regulation of metabolic homeostasis, and plays a key role in the neuroendocrine-immune axis to maintain homeostasis through its afferent and efferent pathways. Vagus nerve stimulation (VNS) refers to any technique that stimulates the vagus nerve, including manual or electrical stimulation. Left ce...

The cholinergic nervous system attenuates the production of pro-inflammatory cytokines and inhibits inflammatory processes. Hence, in animal models of intestinal inflammation, such as postoperative ileus and dextran sulfate sodium-induced colitis, vagus nerve stimulation ameliorates disease activity. On the other hand, in infectious models of microbial peritonitis, vagus nerve activation seemin...

Article abstract—Nonpharmacologic options for the treatment of epilepsy include epilepsy surgery, vagus nerve stimulation, and the ketogenic diet. The advantages and limitations of these treatment modalities have been extensively reviewed, but there is no general consensus on when each option should be considered. The authors propose an algorithm based on the type of epilepsy. Generally, nonpha...

The experiments that have been reported indicate that stimulation of either the right vagus or the left vagus nerve is equally effectual in blocking impulses from the auricles to the ventricles when auricular fibrillation is present. Stimulation of the left vagus nerve is as effectual in blocking impulses from the normally beating auricles as from the auricles when in a state of fibrillation, a...