Objectives: To determine the diagnostic value of the lactate concentration in vaginal secretions in determining the premature rupture of membranes. Subjects and Methods: One hundred 100 pregnant women with single pregnancy of gestational age 20–41 weeks were divided to two groups of 50 each. One group comprised of women with premature rupture of membranes, and the other (control group) of women...

Antiretroviral entry inhibitors are now being considered as vaginally administered microbicide candidates for the prevention of the sexual transmission of human immunodeficiency virus. Previous studies testing the entry inhibitors maraviroc and CMPD167 in aqueous gel formulations showed efficacy in the macaque challenge model, although protection was highly dependent on the time period between ...

'Abstract'Sperm DNA was isolated from vaginal fluid and/or endocervical mucoid plugs at various postcoital intervals. Samples were obtained from 25 volunteer couples. DNA was also prepared from the blood and semen of the couples. The DNA was amplified by polymerase chain reaction (PCR) with DlS8O primers. The Fragment length polymorphism of the amplified products (AMP-FLP) was analysed by acryl...

Objective: Diagnosis of premature rupture of membranes (PROM) is difficult in equivocal cases with traditional methods. This study aimed to evaluate the reliability of vaginal washing fluid urea and creatinine for diagnosis of PROM and to determine the cut off value. Materials and methods: The current study was a prospective case control. Women having gestational age of 28 to 42 weeks were divi...

Introduction: Metritis is one of the causes of maternal morbidity and there are many risk factors for it. Because of the importance of possible association of meconium-stained amniotic fluid and maternal metritis the present study was done to determine whether meconium stained amniotic fluid (MSAF) is associated with puerperal infection. Methods: In this case-control study 150 women with MSAF a...

Studies from women with recurrent vulvovaginal candidiasis (RVVC) and from an animal model of experimental vaginitis suggest that deficiencies in immune function should be examined at the local rather than systemic level. Evidence of vaginal cell-mediated immunity (CMI) was evaluated for the first time in cervicovaginal lavage (CVL) fluid from RVVC patients. Results showed that although constit...

Vaginal leiomyomas are rare benign solid tumours of the vagina. They can cause mechanical dystocia, which is a common problem in obstetrics leading to serious maternal and perinatal complications. Here we describe a patient with a vaginal leiomyoma diagnosed during the mid-trimester that could have caused dystocia. This 22-year-old woman presented with a vaginal mass and leaking vaginal fluid d...

The effect of blood in vaginal fluid on the assay of 6-phosphogluconate dehydrogenase has been studied. Alternative assay procedures have been investigated to overcome these effects.

OBJECTIVE The objectives of this study were to 1) determine the prevalance and characterize the symptomatology of Trichomonas vaginalis (TV) infection in pregnant women on entry into prenatal care in an inner-city population; 2) compare conventional microscopic methods vs. culture techniques in diagnosing TV in both symptomatic and asymptomatic pregnant patients; and 3) correlate wet mount micr...