A facile and convenient synthesis of some novel hydrazones, schiff's base and pyrazoles from thieno[2,3-b]thiophene derivatives 1 have been achieved in high yields assisted by microwave and classical methods. The structures of all the title compounds have been elucidated by elemental analysis, IR, MS, (1)H-NMR and (13)C-NMR. Generally, these findings represent a new class of sulfur and nitrogen...

A rapid and modular continuous flow synthesis of highly functionalized fluorinated pyrazoles and pyrazolines has been developed. Flowing fluorinated amines through sequential reactor coils mediates diazoalkane formation and [3+2] cycloaddition to generate more than 30 azoles in a telescoped fashion. Pyrazole cores are then sequentially modified through additional reactor modules performing N-al...

Among the methods used for synthesis of functionalized heterocyclic compounds, photochemistry has gained immense popularity due to reactivity intermediates in photoinduced reactions. In this study, we report on effect diaryl disulfides as hydrogen atom transfer catalysts transformations pyrazolo[1,2-a]pyrazolones. After excitation with visible light, these compounds are susceptible C–N bond cle...

Non-fluorinated vinyldiazo compounds with trans-configuration irrespective of the nature of 3-R(1)-substituent (R(1) = H, Me, TBSO) even under ambient conditions easily cyclize to produce pyrazoles, while cis-stereoisomers undergo similar ring closure only at elevated temperatures or decompose to produce vinyloxocarbene reaction products. The 3-CF3-substituted analogues with cis- or trans-confi...

A simple, efficient, and environmentally friendly protocol for the synthesis of 1,3,5-triarylpyrazole in [bimm][PF6] ionic liquid mediated by Cu(OTf)2 is described. The reaction protocol gave 1,3,5-triarylpyrazoles in good to high yields (71-82%) via a one-pot addition–cyclocondensation between hydrazines and chalcones, and oxidative aromatization without requirement for an additional oxidizing...