BACKGROUND Growing antibiotic resistance warrants studying nonantibiotic prophylaxis for recurrent urinary tract infections (UTIs). Use of lactobacilli appears to be promising. METHODS Between January 2005 and August 2007, we randomized 252 postmenopausal women with recurrent UTIs taking part in a double-blind noninferiority trial to receive 12 months of prophylaxis with trimethoprim-sulfamet...

Sir, We read with great interest the letter by Nix and Matthias 1 regarding pharmacokinetic considerations relating to tigecycline use in urinary tract infections (UTIs). We agree with the authors that tige-cycline should not be used for UTIs when other therapies including aminoglycosides, carbapenems and colistin are options; however, in rare situations, tigecycline may be considered. In a rec...

The main goal of the management of vesicoureteral reflux (VUR) is prevention of recurrent urinary tract infections (UTIs), and thereby prevention of renal parenchymal damage possibly ensuing from these infections. Long-term antibiotic prophylaxis is common practice in the management of children with VUR, as recommended in 1997 in the guidelines of the American Urological Association. We perform...

We previously described how retail meat, particularly chicken, might be a reservoir for extraintestinal pathogenic Escherichia coli (ExPEC) causing urinary tract infections (UTIs) in humans. To rule out retail beef and pork as potential reservoirs, we tested 320 additional E. coli isolates from these meats. Isolates from beef and pork were significantly less likely than those from chicken to be...

1.1 Incidence and costs UTIs are a major source of morbidity and associated healthcare costs in the United States (US). Community-acquired UTIs largely affect women of reproductive age, with 11% of women experiencing infections each year, one-third of women having an infection by the age of 26, and 60% experiencing at least one infection during their lifetime (Foxman et al., 2000). In 1997, the...

Urinary tract infections (UTIs) are one of the most common infectious diseases of humans, with approximately 150 million cases estimated to occur globally every year. UTIs usually start as a bladder infection (cystitis), but can develop into acute kidney infection (pyelonephritis) and even infection of the bloodstream (urosepsis). The high frequency of UTIs in community and nosocomial settings ...

Urinary tract infections (UTIs) are common in older people and can lead to serious complications. Infections can worsen underlying medical conditions, adversely affect recovery and be alarming to patients, their families and caregivers. UTIs have a complex pathophysiology but the most common cause is the ascent of bacteria from the periurethral area, which explains their prevalence in older wom...

Urinary tract infections (UTIs) are among the most common bacterial infections and account for a significant part of the workload in clinical microbiology laboratories (Micheal et al., 2004). Urinary tract infection (UTI) is one of the most important causes of morbidity in the general population, and is the second most common cause of hospital visits (Das et al., 2006). It has been estimated th...

Background. Urinary tract infections (UTIs) are a frequent problem among postmenopausal women necessitating antimicrobial use, and resistance is increasing. Every year, 8-10% of postmenopausal women have 1 episode of a UTI; of these, 5% will have a recurrence in the next year. Most women have been taken off estrogen hormone replacement therapy (HRT). While studies have demonstrated systemic HRT...

Urinary tract infections (UTIs) are among the most common bacterial infections worldwide. Disproportionately affecting women, UTIs exact a substantial public burden each year in terms of direct medical expenses, decreased quality of life, and lost productivity. Increasing antimicrobial resistance among strains of extraintestinal pathogenic Escherichia coli challenges successful treatment of UTI...