Thousands of women experience uterine factor infertility (UFI).1 Some are born without a womb (Müllerian agenesis)2; others have had a hysterectomy for a myriad of uterine-related pathologies. Many of these women, whether suffering from congenital or acquired uterine infertility, retain a strong desire to be able to bear their own biological child.3 Currently, the only clinically tested option ...

Abstract Introduction Uterine transplantation (UTx) allows women with abnormal uterine factor infertility (AUFI) to have their own biological children. UTx use both living and deceased donations (LD DD), once transplanted, embryos fertilised through IVF are implanted. The aims of this review summarise the history discuss ethical issues surrounding immunosuppression for a ‘life enhancing’ transp...

Even if reproductive medicine has been remarkably successful during the past few decades, with the introduction of in vitro fertilization in the late 1970s and intracytoplasmic sperm injection in the early 1990s, it has been repeatedly mocked by infertility due to an absolute uterine factor. No treatment has been available for the women suffering from an absent or dysfunctional uterus, in terms...

Recipients of organ transplantation on immunosuppressive medications are at increased risk for developing de novo malignancies, including skin cancer, Kaposi's sarcoma, in situ carcinomas of the uterine cervix, anogenital cancers, renal cell carcinoma, and post-transplant lymphoproliferative disorders (PTLD). However, there are few case reports of germ cell tumors after organ transplantation. T...

uterine inversion is shortly described as the indentation and depression of the fundic area extending downwards up to the different levels of the birth canal till vaginal opening. clinical diagnosis of uterine inversion is difficult due to its non-specific symptoms and physical examination. ultrasonography is the most practical modality for radiological evaluation, but it is inadequate to deter...

Human uterus transplantation (UTx) is currently under investigation as a treatment for uterine infertility. Without a uterus transplant, the options available to women with uterine infertility are adoption or surrogacy; only the latter has the potential for a genetically related child. UTx will offer recipients the chance of having their own pregnancy. This procedure occurs at the intersection ...

The aim of this review is to summarize the state-of the-art methods that are used in clinical organ transplantation today, as well as the major findings of recent experimental uterus transplantation (UTx) research regarding organ donation/retrieval, ischemic preservation, surgical techniques for anastomosis, immunosuppression and pregnancy. Absolute uterine factor infertility lacks treatment de...

Abstract Lymphangioleiomyomatosis (LAM) is an estrogen-sensitive lung disease found almost exclusively in women. LAM characterized by the hyperproliferation of smooth muscle cells creating small tumors throughout lungs, resulting formation large cysts that replace normal alveolar space. Growth these and progression cyst development leads to loss pulmonary function, sometimes subsequent transpla...