AIM To assess the feasibility of Microsatellite Instability (MSI) analysis in uterine cavity washings for detecting endometrial cancer in Lynch syndrome. MATERIALS AND METHODS This was a proof-of-concept study in Lynch syndrome patients, scheduled for hysterectomy. At the beginning of surgical procedure, uterine cavity washings were performed, and sent for MSI analysis. Pathological examinati...

Cowden syndrome (CS) is an autosomal dominant disorder characterized by multiple hamartomas in the breast, thyroid and endometrium, with a prevalence of 1 per 250,000. Females with CS have a 21-28% lifetime risk of developing uterine cancer. Germline mutations in the phosphatase and tensin homolog (PTEN) gene, a tumor suppressor gene, are responsible for 30-80% of CS cases. PTEN is a nine-exon ...

The administration and combination of a variety of chemotherapeutic agents for treatment of advanced or recurrent uterine cancer of different histologies is under current debate. Mixed Mullerian Tumors (MMTs), which contain both adenocarcinoma and sarcoma components, are the most rate histologic type and it is therefore difficult to conduct clinical trials to determine if they should be treated...

PURPOSE To retrospectively assess the incidence of sub-serosal and uterine perforation of intra-uterine tandem in intracavitary high-dose-rate (HDR) brachytherapy for cervical cancer, and to evaluate its dosimetric implications on computed tomography (CT)-based treatment planning. MATERIAL AND METHODS Computed tomography images and brachytherapy plans of cervical cancer patients treated from ...

Endometrial cancer arises from the endometrium. It has a slow progression and a reported survival rate of 75%. The identification of soluble biomarkers in the uterine aspirate may be very useful for its early diagnosis. Uterine aspirates from 10 patients with endometrial cancer and 6 non-endometrial cancer controls were analyzed by two-dimensional gel electrophoresis coupled with mass spectrome...

Uterine cervix cancer is one of the leading causes of cancer deaths amongst women in the world (Ferlay et al., 2014). Effective screening programme has been ongoing worldwide, but still the burden of cervical cancers remains high, especially in low income countries where it is the leading cause of cancer in females. In India it has been reported to have the highest disease frequency with 134, 0...

Cancer is the second leading cause of death in the United States, with 52% of deaths caused by cancers of the lung and bronchus, female breast, uterine cervix, colon and rectum, oral cavity and pharynx, prostate, and skin (melanoma). In the 1930s, uterine cancer, including cancer of the uterine cervix, was the leading cause of cancer deaths among women in the United States. With the advent of t...

OBJECTIVE To determine expression of the P2X(7) receptor in normal and in cancer uterine tissues. The rationale was that the receptor P2X(7) regulates constitutive apoptosis in uterine epithelial cells, and previous studies showed diminished P2X(7)-mediated apoptosis in cancer uterine cells compared with normal cells. METHODS A clinical, experimental feasibility study. Normal (n = 42) and can...

cervical cancer is the second most common malignant disease of women worldwide, and accounts for about one tenth of the total number of female cancer deaths. Even though uterine cervical cancer has been decreased as a result of widespread use of effective screening tests for premalig-nant lesions in developed countries, the cancer burden such as incidence and mortality is disproportionately hig...

Spontaneous malignant epithelial tumors of the uterine cervices and cornua rarely occur in mice of most strains. One stock of mice had a high incidence of malignant uterine or cervical tumors. Cancer of the uterine cornua has not been induced experimentally although malignant tumors of the cervix and vagina have been shown, by previous investigations, to occur in mice given estrogen for long pe...