The activities of total extracts and lupane triterpenes, isolated from the stem bark of Acacia mellifera, were evaluated against Plasmodium berghei strain ANKA in a female Swiss mouse model. Five isolated compounds and the crude extracts were evaluated for antimalarial activity and Quinine hydrochloride was used as a positive control. Only betulin and the methanolic extract produced considerabl...

Um novo triterpeno, 3β,22ξ,23ξ-triidróxi-22ξ-acetóxi-24-metil-lanosta-8,24(28)-dieno-31-al, denominado pisosteral, e quatro triterpenos lanostanos conhecidos, 3β,22ξ,23ξ-triidróxi-22ξ-acetóxi24-metil-lanosta-8,24(28)-dieno (pisosterol), 3α,22ξ,23ξ-triidróxi-22ξ-acetóxi-24-metil-lanosta8,24(28)-dieno (3-epi-pisosterol), 3β,22ξ,23ξ-triidróxi-23ξ-acetóxi-24-metil-lanosta-8,24(28)-dieno e 3β,22ξ,23...

Critical survey of a selected class of pentacyclic triterpenes--the oleanane family, is presented based on current literature in order to underline their value for medicinal chemistry and drug development potential. Oleanenes may be considered as a renewable resource of valuable research materials which are structurally diverse, inherently biocompatible and have built-in affinity for many categ...

Four new lanostane triterpenes, colossolactone V (1), colossolactone VI (2), colossolactone VII (3), and colossolactone VIII (4), were isolated from the fruiting bodies of the Vietnamese mushroom Ganoderma colossum, together with the known compound colossolactone E (5). The structures of 1- 4 were assigned on the basis of spectroscopic evidence, and their absolute configurations were determined...

The hindered diene 1 reacts with 3-methylcyclohexenone 6 catalyzed by triflimide to produce the Mukaiyama Michael product 7 (low-temperature quenching) or the [4+2] cycloadduct 8 (quenching at 0 degrees C). Reaction of the hindered diene 23 with 2-methylcyclohexenone 12 with 5:1 AlBr3:AlMe3 afforded a 71% yield of a 1.9:1 mixture of two cycloadducts. Hydrolysis of the major isomer gave the dion...

Three new ursane triterpenes, 3α,19α-dihydroxy-2-nor-urs-12-en-23,28-dioic acid-23-methyl ester (1), 19α,23-dihydroxy-3-oxo-2-nor-urs-12-en-28-oic acid (2), and 2,3-seco-3-methoxy-3,19α,23-trihydroxy-urs-12-en-2-al-28-oic acid (3), were isolated from the MeOH extract of the branch barks of Davidia involucrata, together with six known compounds. Their structures were elucidated by means of vario...

against several kind of sickness including cancer, gastric ulcers, dyspepsia and also useful as an antibacterial and antiinflammatory. Sesquiterpenes, triterpenes, quinone-methide and sesquiterpene pyridine alkaloids have been identified in these species. Maytenus obtusifolia MART. is a plant found in many states of the Northeast and South-east of Brazil, which is used in traditional medicine f...