نتایج جستجو برای: urokinase

تعداد نتایج: 6601  

Journal: :Japanese Journal of Thrombosis and Hemostasis 1990

Journal: :The Journal of Experimental Medicine 1984
J D Vassalli J M Dayer A Wohlwend D Belin

The plasminogen activator (PA) produced by freshly purified human monocytes-macrophages and histiocytic, lymphoma-derived U 937 cells was analyzed by zymography after sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), and found to migrate with an apparent Mr of 55,000, identical to that of urokinase (Uk). By immunoprecipitation with antibodies specific for the two different t...

Journal: :The European respiratory journal 1996
D Bouros S Schiza N Tzanakis J Drositis N Siafakas

Intrapleural urokinase has not been evaluated systemically in terms of efficacy, safety, and cost of treatment in a large series of patients with complicated (parapneumonic) pleural effusions (CPE) and pleural empyemas (PE). Furthermore, the optimal dose and duration of treatment is not known. Twenty consecutive patients with multiloculated parapneumonic effusions (13 with CPE and 7 with PE), i...

Journal: :Neurosciences 2009
Mutasem M Abuhamed Song Zhi Xiao Bo

We present a patient with hydrocephalus after tuberculous meningitis successfully treated with urokinase. She presented with multiple episodes of headache, fever, and vomiting. She underwent external ventricular drainage and was treated with urokinase in addition to dexamethasone, acetazolamide, and 4 antituberculous drugs. She was evaluated clinically, radiologically, and by laboratory work-up...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1985
M P Stoppelli A Corti A Soffientini G Cassani F Blasi R K Assoian

The purified amino-terminal fragment (ATF) of human urokinase plasminogen activator (residues 1-135), which is not required for activation of plasminogen, binds with high affinity to specific plasma membrane receptors on U937 monocytes. Intact urokinase efficiently competes for 125I-labeled ATF binding; 50% competition occurs with 1 nM urokinase. A large part of receptor-bound urokinase remains...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2007
Steven Idell Timothy Allen Shande Chen Kathy Koenig Andrew Mazar Ali Azghani

Intrapleural fibrinolysins have been used to treat pleural loculations. However, the efficacy of clinically available agents has recently been questioned, providing a rationale for investigation of new interventions. Single-chain urokinase plasminogen activator resists inhibition by serpins, and repeated, daily intrapleural administration of this agent prevents intrapleural loculation more effe...

Journal: :Cancer research 1985
S Kohga S R Harvey R M Weaver G Markus

The immunoperoxidase technique, using antibodies against human urinary urokinase (Mr 55,000), was used for the localization of this enzyme in histological preparations of human colon tumors and normal colon tissue. The localization of tissue (vascular) activator was also investigated using antibodies against enzyme purified from human malignant melanoma. Both the "indirect method" and the perox...

Journal: :Journal of periodontal research 2009
R Gonzalez R Arancibia M Cáceres J Martínez P C Smith

BACKGROUND AND OBJECTIVE Tobacco smoking is a significant risk factor for periodontal disease. It has been suggested that smoking may alter connective tissue remodeling in the periodontium. In the present study, we investigated whether cigarette smoke condensate modulates the production of the serine protease urokinase in human gingival fibroblasts. MATERIAL AND METHODS Primary cultures of hu...

Journal: :Journal of cell science 1997
S Bonavaud C Charrière-Bertrand C Rey M P Leibovitch N Pedersen E Frisdal E Planus F Blasi R Gherardi G Barlovatz-Meimon

Urokinase can form a tripartite complex binding urokinase receptor (uPAR) and plasminogen activator inhibitor type-1 (PAI-1), a component of the extracellular matrix (ECM). The components of the tripartite complex are modulated throughout the in vitro myogenic differentiation process. A series of experiments aimed at elucidating the role of the urokinase tripartite complex in the fusion of huma...

Journal: :Hiroshima journal of medical sciences 1981
K Ohmae Y Satow

Urokinase therapy in the treatment of myocardial infarction has been clinically tested with the intent of using its thrombolytic properties to dissolive the embolism and thus prevent any necrotizing effects on the heart muscle. Howeve, during these clinical trials both proper dosage and application method have remained controversial, especially since the therapeutic results have fallen short of...

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