OBJECTIVE To assess the association between sodium and potassium intake and the rise in blood pressure in childhood. DESIGN Longitudinal study of a cohort of children with annual measurements during an average follow up period of seven years. SETTING Epidemiological survey of the population of a suburban town in western Netherlands. SUBJECTS Cohort of 233 children aged 5-17 drawn at rando...

Results Tolvaptan at all doses significantly reduced pulmonary capillary wedge pressure ( 6.4 4.1 mm Hg, 5.7 4.6 mm Hg, 5.7 4.3 mm Hg, and 4.2 4.6 mm Hg for the 15-mg, 30-mg, 60-mg, and placebo groups, respectively; p 0.05 for all tolvaptan vs. placebo). Tolvaptan also reduced right atrial pressure ( 4.4 6.9 mm Hg [p 0.05], 4.3 4.0 mm Hg [p 0.05], 3.5 3.6 mm Hg, and 3.0 3.0 mm Hg for the 15-mg,...

BACKGROUND Biomarkers for mercury (Hg) exposure have frequently been used to assess exposure and risk in various groups of the general population. We have evaluated the most frequently used biomarkers and the physiology on which they are based, to explore the inter-individual variations and their suitability for exposure assessment. METHODS Concentrations of total Hg (THg), inorganic Hg (IHg)...

Ninty-five inhabitants of the gold mining area of Mt. Diwata (on Mindanao, Philippines), who were diagnosed to be mercury (Hg) intoxicated, were orally treated with 2 x 200 mg of the chelating agent DMPS (Dimaval, Co. Heyl, Germany) for 14 days in the course of a UNIDO project focusing on mercury pollution abatement. Blood and urine samples before and after treatment, urine after the first appl...

BACKGROUND Angiotensin-converting enzyme (ACE) inhibitors reduce blood pressure and urine protein excretion and slow the progression of chronic kidney disease. PURPOSE To determine the levels of blood pressure and urine protein excretion associated with the lowest risk for progression of chronic kidney disease during antihypertensive therapy with and without ACE inhibitors. DATA SOURCES 11 ...

BACKGROUND Adrenomedullin 2 (AM2) is a novel member of the calcitonin gene-related peptide family that is thought to play a regulatory role in circulatory homeostasis under normal physiological conditions. The effects of AM2 in heart failure have not been investigated previously. METHODS AND RESULTS Two incremental doses of human AM2 (10 and 100 ng[kg.min] for 90 minutes each) were given by i...

Salem SA, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-221373 Description A 48-year-old man with diabetes mellitus and alcohol abuse presented to the emergency room (ER) with altered mental status, vomiting and abdominal pain. On examination, he was confused and uncooperative with a blood pressure of 70/40 mm Hg, heart rate of 66 beats/min, respiratory rate of 30 breaths/min and oxygen satura...