نتایج جستجو برای: upregulation
تعداد نتایج: 35592 فیلتر نتایج به سال:
Infections due to Candida albicans are usually treated with azole antifungals such as fluconazole, but treatment failure is not uncommon especially in immunocompromised individuals. Relatedly, in vitro studies demonstrate that azoles are nonfungicidal, with continued growth at strain-dependent rates even at high azole concentrations. We hypothesized that upregulation of ERG11, which encodes the...
Background & Objective: Long-term memory depends on protein synthesis. The product of Camkiv gene promotes memory via activating its proteins. The treatment of laboratory animals by Olibanum leads to memory improvement and the recovery of Alzheimer. Therefore, the aim of this study is the evaluation of Olibanum ethanolic extract on the Camkiv expression in PC12 cells. Materials & Methods: Oliba...
Small RNA molecules, such as microRNA and small interfering RNA, have emerged as master regulators of gene expression through their ability to suppress target genes in a phenomenon collectively called RNA interference (RNAi). There is growing evidence that small RNAs can also serve as activators of gene expression by targeting gene regulatory sequences. This novel mechanism, known as RNA activa...
PURPOSE To evaluate the mRNA and protein expressions of NLRP3 inflammasome and its downstream inflammatory factors in human dry eye. METHODS We recruited 54 patients with Sjögren's syndrome dry eye (SSDE), 50 patients with non-Sjögren's syndrome dry eye (NSSDE), and 46 healthy controls. Tear film breakup time (TBUT), Schirmer I test, and fluorescein staining (FL) were performed on all subject...
Selected Reading McPherron, A.C., Lawler, A.M., and Lee, S.J. (1999). Nat. Genet. 22, 260–264. Bogdanovich, S., Krag, T.O.B., Barton, E.R., Morris, L.D., WhitteMcPherron, A.C., Lawler, A.M., and Lee, S.J. (1997). Nature 387, more, L., Ahima, R.S., and Khurana, T.S. (2002). Nature 420, 418–421. 83–90. Bullough, W.S. (1965). Cancer Res. 25, 1683–1727. Nakashima, M., Toyono, T., Akamine, A., and J...
Radiation-induced heart toxicity is one of the serious side effects after a radiation disaster or radiotherapy for patients with chest cancers, leading to a reduction in the quality of life of the patients. Evidence has shown that infiltration of inflammatory cells plays a key role in the development of functional damages to the heart via chronic up-regulation of some pro-fibrotic and pro-infl...
PURPOSE Ceruloplasmin (Cp) expression is increased locally as a response to many neurodegenerative conditions. The purposes of this study were to confirm findings of Cp upregulation in glaucoma, detect the time course of this upregulation in a glaucoma model, and better localize its expression in the retina. METHODS mRNA and protein were extracted from the retina and brain of DBA/2 and C57BL/...
Chromosome 14 open reading frame 166 (C14orf166) encodes a 28‑kDa nuclear and cytoplasmic protein that is involved in viral infection, RNA metabolism, centrosome structure. It binds to the polymerase acidic subunit of influenza A virus, which associated with several transcription factors, II, activate initiation promote virus infection. also interacts mature hepatitis C core regulate infection ...
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