نتایج جستجو برای: uplc

تعداد نتایج: 3067  

Journal: :Cancer research 2011
Andrew D Patterson Olivier Maurhofer Diren Beyoglu Christian Lanz Kristopher W Krausz Thomas Pabst Frank J Gonzalez Jean-François Dufour Jeffrey R Idle

There has been limited analysis of the effects of hepatocellular carcinoma (HCC) on liver metabolism and circulating endogenous metabolites. Here, we report the findings of a plasma metabolomic investigation of HCC patients by ultraperformance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry (UPLC-ESI-QTOFMS), random forests machine learning algorithm, a...

2015
Sandra Gouveia-Figueira Jana Späth Angela M. Zivkovic Malin L. Nording Michael Müller

Bioactive lipids, including oxylipins, endocannabinoids, and related compounds may function as specific biochemical markers of certain aspects of inflammation. However, the postprandial responsiveness of these compounds is largely unknown; therefore, changes in the circulating oxylipin and endocannabinoid metabolome in response to a challenge meal were investigated at six occasions in a subject...

2016
Matthias D’Hondt Bert Gevaert Evelien Wynendaele Bart De Spiegeleer

A newly developed single quad mass spectrometry (MS) detector was coupled to a ultra-high performance liquid chromatography (UPLC) system and implemented in the routine quality control (QC) and impurity analysis of four therapeutic peptides, namely bleomycin sulfate, tyrothricin, vancomycin HCl and bacitracin, which were selected given their multi-component drug nature and their closely structu...

Journal: :Molecules 2015
Wanli Zhao Xiaoqiang Huang Xiaoyan Li Fangfang Zhang Sainan Chen Miao Ye Mingqing Huang Wen Xu Shuisheng Wu

Alismatis Rhizoma (AMR) is a well-known natural medicine with a long history in Chinese medicine and has been commonly used for treating a wide range of ailments related to dysuria, edema, nephropathy, hyperlipidaemia, diabetes, inflammation as well as tumors in clinical applications. Most beneficial effects of AMR are attributed to the presence of protostane terpenoids, the major active ingred...

Journal: :Acta poloniae pharmaceutica 2012
Ashok Kumar Gautam Saini Anroop Nair Rishbha Sharma

The pharmaceutical companies today are driven to create novel and more efficient tools to discover, develop, deliver and monitor the drugs. In this contest the development of rapid chromatographic method is crucial for the analytical laboratories. In precedent decade, substantial technological advances have been done in enhancing particle chemistry performance, improving detector design and in ...

Journal: :Journal of chromatographic science 2014
Mary Wharton Michael Geary Paul Sweetman Laura Curtin Niamh O'Connor

A simple, rapid ultra-performance liquid chromatography (UPLC) method was developed for the analysis of itraconazole and its associated production impurities. The optimum chromatographic conditions were achieved using an Agilent Zorbax Eclipse XDB C18 column, 1.8 µm (4.6 × 50 mm) installed in a column oven heater utilizing a gradient mobile phase of 0.08M tetrabutylammonium hydrogen sulfate buf...

2017
Jin-Fa Tang Wei-Xia Li Fan Zhang Yu-Hui Li Ying-Jie Cao Ya Zhao Xue-Lin Li Zhi-Jie Ma

Background Nowadays, Radix Polygoni Multiflori (RPM, Heshouwu in Chinese) from different geographical origins were used in clinic. In order to characterize the chemical profiles of different geographical origins of RPM samples, ultra-high performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-QTOF/MS) combined with chemometrics (partial least squared discriminant an...

2017
Hae In Bang Mi-Ae Jang Yong-Wha Lee

The demand for rapid and broad clinical toxicology screens is on the rise. Recently, a new rapid toxicology screening test, the Triage TOX Drug Screen (Alere Inc., USA), which can simultaneously detect 11 drugs of abuse and therapeutic drugs with an instrument-read cartridge, was developed. In the present study, we evaluated the efficacy of this new on-site immunoassay using 105 urine specimens...

Journal: :Biomedical chromatography : BMC 2014
Bushra T Al-Quadeib Mahasen A Radwan Lidija Siller Elaine Mutch Ben Horrocks Matthew Wright Abdulaziz Alshaer

Amphotericin B (AmB) is the first-line agent for the treatment of life-threatening invasive fungal infections. The aim of this study was to monitor AmB in critically ill Saudi patients in ICU after i.v. administration of 0.68 ± 0.1 mg/kg/day Fungizone®. A selective, sensitive and precise UPLC MS/MS method was developed to measure AmB concentrations in these patients. Seven ICU patients with cre...

2016
Miaoling Li Xiongze Zhang Nanying Liao Baikang Ye Yuting Peng Yuying Ji Feng Wen

Polypoidal choroidal vasculopathy (PCV), the predominant subtype of neovascular age-related macular degeneration in the Asian population, is associated with genetic polymorphism of lipid metabolism. In this study, we performed the untargeted lipidomics approach of ultra-performance liquid chromatography coupled with mass spectrometry (UPLC-MS) to reveal the potential discriminating lipid profil...

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