cutaneous leishmaniasis is a common tropical dermatose with diverse clinical presentations. at times, it may appear in unusual shape or unusual site that causes diagnostic challenge. we reported a case of unusual presentation of cutaneous leishmaniasis which appeared as an ulcer on the lower lip of a ten-year-old boy. the diagnosis was confirmed by identifying leishmania parasites at ulcer smea...

hypothyroidism is usually associated with delayed pubertal development but in rare occasions precocious puberty may ensue which is seen in cases of prolonged and untreated hypothyroidism. this is also called the van wyk grumbach syndrome. here we present 4 cases of precocious puberty due to hypothyroidism.

Congenital hypopituitarism is a rare condition associated with possible serious complications and long-term neurological sequelae, if not promptly recognized and treated.1 Neonates with congenital hypopituitarism may present with or without associated developmental defects, such as ocular, midline, and genital abnormalities. They may also present with nonspecific symptoms, including hypoglycemi...

swelling of both ankle joints the next day. He complained of limping. At 16-00 hours on 15 September he developed sudden pain in the left side of the scrotum, which rapidly increased in severity. The purpuric rash now involved both lower extremities, the perineum, the suprapubic region, and both buttocks. The patient was the second of three boys in the family. He was born a: full term, delivere...

A 35-year-old man presented with a 3-year history of arthralgia and purple coloration of the skin of his fingers and feet. Hand and foot radiography showed cystic bone lesions on phalanges suggestive of sarcoidosis. Lab tests revealed increased liver enzymes. Liver MRI evidenced an enlarged liver and retroperitoneal lymphadenopathy. Histological analysis of the finger skin, lymph nodes and live...