Early in 1961 a city-wide oral poliomyelitis vaccination program was under-taken in the city of Middletown, Connecticut by the and his staff. A description of various aspects of this so-called mass vaccination project follows in the papers that make up this issue of THE YALE JOURNAL OF BIOLOGY AND MEDICINE. In the Middletown program some 10,000 children under the age of 18 received oral poliovi...

  Stability study of biological products plays an important role for determination of product changes in maintenance period and ensuring of safety and efficacy of vaccines. In this research, accelerated and long-term stability study performed for six batches of full and reduced-dose cattle Iriba strain brucellosis vaccine that manufactured by Razi vaccine and serum research institute as a new v...

We propose the minicommunity design to estimate indirect effects of vaccination. Establishing indirect effects of vaccination in unvaccinated subpopulations could have important implications for global vaccine policies. In the minicommunity design, the household or other small transmission unit serves as the cluster in which to estimate indirect effects of vaccination, similar to studies in lar...

Objectives Venous thrombosis and thrombocytopenia after vaccination with the adenovirus-vectored COVID-19 vaccine ChAdOx1 nCov-19 (AstraZeneca) have been linked to serum antibodies against platelet factor 4 (PF4)-polyanion complexes. We here report vaccine-induced isolated carotid arterial thrombosis. Methods Imaging laboratory findings, treatment decisions, outcome of this case are presented. ...

Background: Haemophagocytic lymphohistiocytosis (HLH) is a rare and potentially life-threatening systemic hyperinflammatory disease, which can have several aetiologies. Clinical case: 48-year-old woman affected by transfusion-dependent ?-thalassemia was hospitalized in our haematology unit presenting with intermittent fever, haepatosplenomegaly pancytopenia, developed few days after the booster...

stability study of biological products plays an important role for determination of product changes in maintenance period and ensuring of safety and efficacy of vaccines. in this research, accelerated and long-term stability study performed for six batches of full and reduced-dose cattle iriba strain brucellosis vaccine that manufactured by razi vaccine and serum research institute as a new vac...

AIMS International adoption medicine is a relatively new specialty in pediatrics that has emerged to address the specific health care needs of internationally adopted children in high-income countries. This study ascertains the seroprotection rate for vaccine-preventable diseases, especially against pneumococcal diseases. PATIENTS AND METHODS We evaluated 67 internationally adopted children t...

The national reporting system for infectious diseases in the United States was initially an archival system designed to document trends in disease occurrence rather than to provide epidemiologically important information needed for prevention and control of diseases. As national immunization programs developed, so did the need for surveillance of vaccine-preventable diseases. The first major su...

During the summer of 1930, a very severe epidemic of cholera broke out in several villages of the Faridpur district, accounting for a total of 3,445 cases amongst a population of only 256,249; of the latter, 52,295 were inoculated at the beginning of the epidemic with one cubic centimetre of cholera vaccine prepared in the Bengal Vaccine Laboratory with local strains. As in some instances a few...