meloxicam is a poorly water soluble non steroidal anti-inflammatory drug and antipyretic agent. the aim of the present work was to investigate the effect of different types of carriers on in vitro dissolution of meloxicam. meloxicam solid dispersions were prepared by physical mixing, co-grinding and solvent evaporation methods with polyethylene glycol (peg) 6000. the effect of solubilization by...

Dispersions of colloidal particles in aqueous media are widely investigated because of their use in many industrial applications (foods, pharmaceuticals, cosmetics, paints, etc.). Acid-hydrolyzed chitin has been reported to spontaneously disperse into colloidal rod-like crystalline particles, which can form rigid structures. Such colloidal dispersions of acid-degraded chitin can undergo an isot...

PURPOSE The aim of the present investigation was preparation and characterization of sirolimus solid dispersions by solvent evaporation technique to improve its dissolution properties. METHODS Polyvinylpyrrolidone (PVP), Poloxamer 188 and Cremophore RH40 were used to prepare the solid dispersions of sirolimus. In vitro dissolution study using USP type I apparatus, were performed in distilled ...

Dwarf galaxies are ubiquitous throughout the universe and extremely sensitive to various forms of internal external feedback. Over last two decades, census dwarf in Local Group beyond has increased markedly. While hydrodynamic simulations (e.g. FIRE II, MINT Justice League) have reproduced observed properties down ultra-faints, such require extensive computational resources run. In this work, w...

Pharmaceutical availability of diazepam, oxazepam and nitrazepam from solid dispersions of PEG 6000 have been studied in comparison with corresponding physical mixtures and pure benzodiazepines. Selected derivatives of 1,4-benzodiazepin-2-one are poorly water soluble drugs. The aim of this work was to report the properties of diazepamand nitrazepam-PEG 6000 solid dispersions. Differential scann...

The preparation of highly stable water dispersions of silver nanoparticles using the naturally available gellan gum as a reducing and capping agent is reported. Further, exploiting the gel formation characteristic of gellan gum silver nanoparticle incorporated gels have also been prepared. The optical properties, morphology, zeta potential and long-term stability of the synthesized silver nanop...

In this work we publish stellar velocity dispersions, sizes, and dynamical masses for 8 ultra-massive galaxies (UMGs; log($M$/M$_\odot>11$, $z\gtrsim3$) from the Massive Ancient Galaxies At $z>3$ NEar-infrared (MAGAZ3NE) Survey, more than doubling number of such with dispersion measurements at epoch. Using deep Keck/MOSFIRE Keck/NIRES spectroscopy these objects in $H$- $K$-bandpasses, obtain la...

solid dispersions in water-soluble carriers have attracted considerable interest as a means of improving the dissolution rate, and hence possibly bioavailability, of a range of hydrophobic drugs. the poor solubility of carvedilol leads to poor dissolution and hence variation in bioavailability. the purpose of the present investigation was to increase the solubility and dissolution rate of carve...

Solid dispersions of carbamazepine or ethenzamide were prepared by melting and rapid cooling with liquid nitrogen using lactose as a carrier. The physical characteristics of these solid dispersions were investigated by powder X-ray diffraction, differential scanning calorimetry, and dissolution rate analysis. The degree of crystallinity of the drugs in solid dispersions decreased with decreases...

Maghemite (γ-Fe2O3) nanoparticles (NPs) can be successfully dispersed in a protic ionic liquid, ethylammonium nitrate (EAN), by transfer from aqueous dispersions into EAN. As the aqueous systems are well controlled, several parameters can be tuned. Their crucial role towards the interparticle potential and the structure of the dispersions is evidenced: (i) the size of the NPs tunes the interpar...