BACKGROUND AND AIMS Our study evaluated the prevalence, the characteristics and implications of the upper gastrointestinal localisation (UGI+) in paediatric Crohn's Disease (CD) patients. METHODS This prospective study evaluated 45 newly diagnosed CD patients at diagnosis and follow up with respect to CD localisation. RESULTS All patients presented CD at the colon and/or ileum. In 24/45 pat...

An Ugi four-component reaction of propargylamine with 3-formylindole and various acids and isonitriles produces adducts which are subjected to a cationic gold-catalyzed diastereoselective domino cyclization to furnish diversely substituted spiroindolines. All the reactions run via an exo-dig attack in the hydroarylation step followed by an intramolecular diastereoselective trapping of the immin...

We describe the development of a novel synthesis strategy that uses common reaction conditions to transform a collection of simple building blocks into complex molecules bearing a terminal difluoromethyl group. The core of this approach is the conscious design and synthesis of new difluorinated building blocks which contain inactive and reactive groups on each side of the CF(2) group. The strat...

Various isocyanide-based multicomponent reactions prove to be highly reliable when ?-substituted ?-amino boronic esters are employed as the amine component, allowing efficient synthesis of unprecedented peptidomimetics and heteroatom-rich boron-containing small molecules. In particular, scope Ugi reaction is widely exploited, give a family enantiopure ?-amido boronates. The Ugi-azide van Leusen...

BACKGROUND/PURPOSE The appropriate role for ultrasonography (US) as a replacement for the upper gastrointestinal series (UGI) in vomiting infants remains undefined. The authors have used decision analysis techniques to determine whether the use of ultrasonography as an initial screen in vomiting infants is cost effective when compared with the UGI as the only study. METHODS Two diagnostic str...

An operationally simple protocol for the synthesis of 2,3-dihydrobenzo[f][1,4]oxazepin-3-ones, based on an Ugi reaction of an ortho-(benzyloxy)benzylamine, glycolic acid, an isocyanide and an aldehyde, followed by an intramolecular Mitsunobu substitution was developed. The required ortho-(benzyloxy)benzylamines have been in situ generated from the corresponding azides, in turn prepared in high ...