in this study 50 samples of ecstasy tablets seized in iran during the period of 2007 through 2008 were examined and their physical characteristics (appearance, marking, scored/not scored, color, weight, diameter, thickness) were determined. in order to determine the chemical characteristics of these tablets, color tests (marquis test, simon’s test, chen’s test and gallic acid test), thin layer ...

Tablets containing metoprolol succinate and Compritol(®) 888ATO in the ratio of 1:2 yielded the desired sustained release profile in phosphate buffer pH 6.8 when evaluated using USP type II paddle apparatus and was selected as the optimized formulation. Robustness of optimized formulation was assessed by studying the effect of factors like varying source of metoprolol succinate and Compritol(®)...

Both the Valsartan (VAL) and Olmesartan medoxomil (OLM) are widely prescribed anti-hypertensive agents with angiotensin II type I receptor antagonistic activity. VAL OLM of BCS class drugs having a low variable oral bioavailability. Recrystallization from different organic solvents improved its aqueous solubility thereby in vitro dissolution properties. In present investigation, tablets contain...

Controlled release (CR) Ciprofloxacin (CFX) matrix tablets were prepared using Ciprofloxacin betaine as a model drug and Kollidon SR as a core matrix former. Kollidon SR embedded CFX matrix tablets were then characterized with Carbopol 974P NF, Cetyl alcohol, Hydroxypropyl methyl cellulose (HPMC 4.5 cps). CFX release was 74% after 10 hours dissolution in 0.01 N HCl solution from the tablets con...

The study was aimed at developing extended release matrix tablets of poorly water-soluble diclofenac sodium and highly water-soluble metformin hydrochloride by direct compression using cashew gum, xanthan gum and hydroxypropylmethylcellulose (HPMC) as release retardants. The suitability of light grade cashew gum as a direct compression excipient was studied using the SeDeM Diagram Expert System...

Lorazepam a benzodiazepine drug is used as an antianxiety, sedative, hypnotic, and anticonvulsant drug. Bypassing the enterohepatic recirculation and first-pass metabolism of lorazepam by sublingual delivery of this drug may accelerate the onset of its action. The objective of this study was the formulation, optimization and in vitro characterization of mucoadhesive sublingual tablets of loraze...

Objective. To observe the clinical prophylactic and therapeutic efficacy of Liuwei Dihuang Pills and Ginkgo Leaf Tablets for type 2 diabetic vascular complications. Methods. It was a randomized, double-blind and placebo-controlled clinical trial. 140 outpatients with type 2 diabetes were recruited and randomly divided into the treatment group and control group. The two groups were given basic t...

The investigation was concerned with design and characterization of oral controlled release matrix tablets of Zidovudine (AZT) in order to improve efficacy and better patient compliance. Tablets were prepared by direct compression method using various proportion of hydrophilic polymer viz; Eudragit RS100 and RL100 along or in combination with hydrophobic polymer ethyl cellulose. In vitro releas...

The present study was carried out to develop oral controlled release matrix tablets and three layer matrix tablets of highly water soluble diltiazem HCl using natural polymers Xanthan gum (XG), locust bean gum (LBG) and a mixture XG: LBG in 1:1 ratio as matrix forming agent, and anionic Sodium Carboxyl Methyl Cellulose as release retardant layer on the matrix core, Di calcium Phosphate (DCP) an...

The most pervasive problems today include the burden of disease and its complexities. While diabetes is not an infectious disease, it caused by a healthy diet bad eating habits. causes are unhealthy dietary patterns, attributable to insufficient pancreas insulin secretion receptor insensitivity, process wisdom. It results in improper glucose metabolism reuptake into muscles. Various synthetic d...