PURPOSE This study aimed to explore the role of the Twist gene in the epithelial-mesenchymal transition of ovarian cancer. METHODS An RNA interference plasmid expressing a small interfering RNA (siRNA)-targeting Twist (Twist siRNA vector) was designed, constructed, and transfected into the human ovarian cancer cell line A2780. Transfection efficiency was assessed under a fluorescence microsco...

die erlebnislyrik umfasst die gedichte, in denen es um die erinnerung eines lyrischen ichs an ein geschehen geht, wobei mit dem gedichtschreiben ein erinnerungsvorgang in gang gesetzt wird, der einen bezug zwischen dem erlebenden ich und dem geschehen schafft und damit ein unmittelbares erleben erzeugt. die speziellen mittel der lyrik wie reim, rhythmik, klang, melodie, wiederholung, bildsprach...

Twist, a key regulator of epithelial-mesenchymal transition (EMT), plays an important role in the development of a tumorigenic phenotype. Energy metabolism reprogramming (EMR), a newly discovered hallmark of cancer cells, potentiates cancer cell proliferation, survival, and invasion. Currently little is known about the effects of Twist on tumor EMR. In this study, we found that glucose consumpt...

es wird gezeigt, dass bei der standiger zunahme der production von roheisen ,die fast ausschliesslich in hochofen erfolgt, der gestelldurchmesser und die ofeneinheit zunimmt demgegenuber der spezifische brennstoffverbrauch abnimmt. weiterhin wird die entwicklungsrichtung der stahlerzeungsverfanren wegen der wirtschaftlichen und technischen hinsicht untersucht und festgestellt, dass nuter versch...

The transcription factor TWIST is an important factor in regulating epithelial-mesenchymal transition (EMT) and tumor metastasis. To explore the functions of TWIST in hypopharyngeal cancer, we investigated if overexpression of TWIST has an effect on FaDu cell morphology, and if alteration of TWIST has an effect on E-cadherin, N-cadherin, c-fos, MM...

The effect of D-cycloserine on the establishment of twist states in Bacillus subtilis macrofibers was examined. Macrofibers produced in the presence of the drug differed in twist compared with those produced in its absence. The degree of twist alteration was dependent on the concentration of D-cycloserine in the growth medium. Macrofibers of different twist states representative of the entire t...

Basic helix-loop-helix (bHLH) transcription factors are known as key regulators for mesenchymal differentiation. The present study showed that overexpression of Twist-1, a bHLH transcription factor, suppresses bone morphogenetic protein (BMP)-induced osteoblast differentiation, and downregulation of endogenous Twist-1 enhances BMP signaling. Maximal inhibition of BMP signaling was observed when...

BACKGROUND Epithelial-mesenchymal transition (EMT) is associated with tumor hypoxia. EMT is regulated, in part, by the action of TWIST, which inhibits of E-cadherin expression and may interfere with the p53 tumor-suppressor pathway. METHODS We examined the expression of TWIST, E-cadherin, hypoxia-inducible factor 1α (HIF1α), and p53 by immunohistochemistry in 123 cases of ovarian epithelial c...