Complement-dependent cytotoxicity in tumor bearer sera (TBS) from Wistar rats carrying any of five transplantable aminoazo dye-induced hepatomas (D23, D33, D23/Not, D30, or D202) were investigated by a short-term 51Cr release assay. Extensive tests of various TBS against the hepatomas revealed that the tumors could be divided into two groups. Group 1 hepatomas (D23, D33, and D23/Not) all shared...

The priming of an immune response against a major histocompatibility complex class I-restricted antigen expressed by nonhematopoietic cells involves the transfer o f that antigen to a host bone marrow-derived antigen presenting cell (APC) for presentation to CD8 + T lymphocytes. Dendritic cells (DC), as bone marrow-derived APC, are first candidates for presentation o f tumorassociated antigens ...

Purpose: Medulloblastoma in children can be categorized into at least four molecular subgroups, offering the potential for targeted therapeutic approaches to reduce treatment-related morbidities. Little is known about the role of tumor microenvironment in medulloblastoma or its contribution to these molecular subgroups. Tumor microenvironment has been shown to be an important source for therape...

Monoclonal antibodies (MAbs) COL-4 and COL-12, to the carcinoembryonic antigen (CEA), and B72.3, CC-49, CC-83, to the tumor-associ ated glycoprotein 72 (TAG-72), were used to study the expression of distinct epitopes of the two molecules in 71 cases of lung carcinoma of differing histotype. These MAbs reacted with the majority of adenocarcinomas by immunoperoxidase on tissue sections, but demon...

Significant progress has been made over the last decade towards realizing the potential of natural killer (NK) cells for cancer immunotherapy. NK cells can respond rapidly to transformed and stressed cells, and have the intrinsic potential to extravasate and reach their targets in almost all body tissues. In addition to donor-derived primary NK cells, also continuously expanding cytotoxic cell ...

Interleukin (IL)-21 modulates T-cell–associated, B-cell– associated, and natural killer cell–associated immunity. However, the potential of IL-21 to simultaneously stimulate cellular and humoral antitumor responses and the mechanisms involved have not yet been adequately explored. In this report, we examined the immune-modulating effect of IL-21 when used in vitro and its adjuvant effects when ...

The innate cellular and molecular components required to mediate effective vaccination against weak tumorassociated antigens remain unclear. In this study, we used polymeric cancer vaccines incorporating different classes of adjuvants to induce tumor protection, to identify dendritic cell (DC) subsets and cytokines critical to this efficacy. Three-dimensional, porous polymer matrices loaded wit...

Purpose: Clustering of neural autoantibodies in patients with paraneoplastic neurologic disorders may predict tumor type. A mathematical analysis of neural autoantibody clusters was performed in 78,889 patients undergoing evaluation for a suspected paraneoplastic autoimmune neurologic disorder. Tumor predictive autoantibody profiles were confirmed in sera from patients with histologically prove...

Recently, Means and Krantz showed that the inhibition of erythroid colony-forming units caused by interferon-y (IFN-y) can be corrected invitro by recombinant human erythropoietin (EPO).' In vivo, the pathogenetic mechanism of the anemia of chronic disease (ACD) is not yet understood. Because this symptom is very common, many attempts have been made to explore the factors involved and to establ...

mission until the occurrence of the cerebral hemorrhage. A 69-year-old woman reported acute headache, vomiting and blurred vision. Clinical examination showed a homonymous hemianopia to the right side and somnolence. At this time, cranial computed tomography demonstrated an atypically located intracranial hemorrhage in the left parieto-occipital region ( fig. 1 ). As somnolence rapidly progress...