نتایج جستجو برای: tumor vaccine

تعداد نتایج: 530475  

Journal: :Bioscience, Biotechnology, and Biochemistry 2007

2010
Shigeo Koido Sadamu Homma Eiichi Hara Yoshihisa Namiki Akitaka Takahara Hideo Komita Eijiro Nagasaki Masaki Ito Toshifumi Ohkusa Jianlin Gong Hisao Tajiri

The goal of cancer vaccines is to induce antitumor immunity that ultimately will reduce tumor burden in tumor environment. Several strategies involving dendritic cells- (DCs)- based vaccine incorporating different tumor-associated antigens to induce antitumor immune responses against tumors have been tested in clinical trials worldwide. Although DCs-based vaccine such as fusions of whole tumor ...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2005
Fanny Chagnon Simon Tanguay Ozdem Levent Ozdal Meng Guan Zeynep Z Ozen Jean-Sébastien Ripeau Mario Chevrette Mostafa M Elhilali Lu Ann Thompson-Snipes

PURPOSE An ideal vaccine therapy for tumors should activate both effector and memory immune responses against tumor-specific antigens. Here we investigated the effect of CpG oligodeoxynucleotides (CpG-ODN) for their ability to potentiate the activity of tumor antigen-pulsed bone marrow-derived dendritic cells (DC) in a vaccine model for the treatment of murine renal cell carcinoma (RENCA). EX...

2015
Jie Ji Zhixia Fan Feifan Zhou Xiaojie Wang Lei Shi Haiyan Zhang Peiru Wang Degang Yang Linglin Zhang Wei R. Chen Xiuli Wang

Dendritic cell (DC) based vaccines have emerged as a promising immunotherapy for cancers. However, most DC vaccines so far have achieved only limited success in cancer treatment. Photodynamic therapy (PDT), an established cancer treatment strategy, can cause immunogenic apoptosis to induce an effective antitumor immune response. In this study, we developed a DC-based cancer vaccine using immuno...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2010
Richard J Barth Dawn A Fisher Paul K Wallace Jacqueline Y Channon Randolph J Noelle Jiang Gui Marc S Ernstoff

PURPOSE To determine whether an autologous dendritic cell (DC) vaccine could induce antitumor immune responses in patients after resection of colorectal cancer metastases and whether these responses could be enhanced by activating DCs with CD40L. EXPERIMENTAL DESIGN Twenty-six patients who had undergone resection of colorectal metastases were treated with intranodal injections of an autologou...

2013
Mohan Karkada Tara Quinton Rachelle Blackman Marc Mansour

A successful cancer vaccine needs to overcome the effects of immune-suppressor cells such as Treg lymphocytes, suppressive cytokine-secreting Tr1 cells, and myeloid-derived suppressor cells (MDSCs), while enhancing tumor-specific immune responses. Given the relative poor efficacy associated with current cancer vaccines, a novel vaccine platform called DepoVax(TM) (DPX) was developed. C3 tumor-c...

2011
Jia-Ming Chang Le-Mei Hung Yau-Jan Chyan Chun-Ming Cheng Rey-Yuh Wu

Carthamus tinctorius (CT), also named safflower, is a traditional Chinese medicine widely used to improve blood circulation. CT also has been studied for its antitumor activity in certain cancers. To investigate the effects of CT on the dendritic cell (DC)-based vaccine in cancer treatment, cytokine secretion of mouse splenic T lymphocytes and the maturation of DCs in response to CT were analyz...

Journal: :Human gene therapy 2000
A E Chang Q Li D K Bishop D P Normolle B D Redman B J Nickoloff

We performed a clinical study of five patients with melanoma to evaluate the immunobiological effects of retrovirally transduced autologous tumor cells given as a vaccine to prime draining lymph nodes. Patients were inoculated with both wild-type (WT) and GM-CSF gene-transduced tumor cells in different extremities. Approximately 7 days later, vaccine-primed lymph nodes (VPLNs) were removed. The...

2014
Zuzana Berrong Shamim Ahmad Rasha Abu Eid Abdeljabar El Andaloussi Tanusree Sen Ross Stewart Scott A Hammond Rajeev Shrimali Mikayel Mkrtichyan Samir N Khleif

Enhancing an effector immune response by cancer vaccines has not been clinically successful so far. Although the necessary immune response may be elicited using vaccine-based therapies, this has not been sufficient for a positive clinical outcome; since most cancers can escape immune surveillance via multiple immune suppressive mechanisms induced in the tumor environment. A relatively recent st...

2014
Sanghoon Kwon Young-Eun Kim Jeong-A Park Doo-Sik Kim Hyung-Joo Kwon Younghee Lee

Molecular-targeted therapy has gained attention because of its high efficacy and weak side effects. Previously, we confirmed that transmembrane 4 superfamily member 5 protein (TM4SF5) can serve as a molecular target to prevent or treat hepatocellular carcinoma (HCC). We recently extended the application of the peptide vaccine, composed of CpG-DNA, liposome complex, and TM4SF5 peptide, to preven...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید