Objectives and Background: Mutation directed inactivation of the tumor suppressor gene p53 have been found incountries with high frequency for hepatocellular carcinomas (HCCs). Our goal in the present study was screening of the p53 gene in tumor tissues from HCC affected individuals in southwest Iran for putative mutations in exons 7 and 8 that are known as hot spot regions. Materials & Met...

background: melanoma progression and metastasis is suggested to be mediated by increased accumulation of myeloid derived suppressor cells. various chemotherapeutic drugs such as 5-fluorouracil in single low concentration have the capacity, at least in part, to reverse tumor progression by reducing myeloid derived suppressor cellsmediated immunosuppression. objective: to assess whether multiple ...

Mitochondrial dysfunction and respiratory function changes have been consistently associated with the initiation progression of cancer. The purpose this study was to retrospectively investigate expression mitochondrial tumor-suppressor DNA-repair proteins in patients oral squamous cell carcinoma (OSCC) evaluate relationship between their prognosis. We enrolled 197 OSCC who underwent surgical re...

Urinary-tract-related tumors are prone to simultaneous or heterogeneous multiple tumor development within the primary organ. Urologic have a very high risk of recurrence in long and short term. This may be related disruption homeostasis on genetic level, such as induction mutations due exposure various carcinogenic factors cancer suppressor gene functions. It is essential detect progression sig...

Introduction: Von Hippel-Lindau disease (VHL) is autosomal dominant tumor syndrome that debuts mostly in young adults , patients with this are linked to the triggering of various types benign and malignant neoplasms multiple locations, systems organs, particular affecting more nervous system other internal organs. Approximately shows an incidence rate 1 36,000 live births a penetrance greater t...