Macrophages are a major source of proinflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha), which are expressed during conditions of inflammation, infection, or injury. We identified an activity secreted by a macrophage tumor cell line that negatively regulates bacterial lipopolysaccharide (LPS)-induced expression of TNF-alpha. This activity, termed TNF-alpha-inhibiting factor ...

Tumor necrosis factor alpha (TNF-alpha) is the key mediator of superantigen-induced T cell lethal shock. Here, we show that nuclear factor of activated T cells transcription factor, NFATp, controls susceptibility to superantigen-induced lethal shock in mice through its activation of TNF-alpha gene transcription. In NFATp-deficient mice, T cell stimulation leads to delayed induction and attenuat...

PURPOSE Tumor necrosis factor-alpha (TNF-alpha) enhances radiotherapy (RT) killing of tumor cells in vitro and in vivo. To overcome systemic side effects, we used a bispecific antibody (BsAb) directed against carcinoembryonic antigen (CEA) and TNF-alpha to target this cytokine in a CEA-expressing colon carcinoma. We report the evaluation of this strategy in immunocompetent CEA-transgenic mice. ...

Introduction: The role of adipose tissue as energy storage and endocrine organ is an area interest in the treatment several diseases. This study aimed to evaluate blood adiponectin (ADP), leptin, tumor necrosis factor type alpha (TNF-alpha) concentrations, their prognostic value patients with exacerbated chronic heart failure (CHF). Methods results: following were assessed 64 consecutive hospit...

conclusions special high-risk groups, including patients with ltbi, should be treated before receiving tnf-α inhibitors. the tuberculin skin test (tst) is a somewhat cost-effective test for the diagnosis of ltbi. however, its usefulness with respect to false results should be re-evaluated in this situation. results there were somewhat different approaches proposed by various researchers regardi...

objective(s): acquisition of tnf-α resistance plays role in the onset and growth of malignant tumors. previous studies have demonstrated that mcf-7 cell line and its doxorubicin resistant variant mcf-7/adr are resistant against the cytotoxic effects of tnf-α. in this study, we investigated the role of akt activation in resistance of mcf-7 and mcf-7/adr against tnf-α cytotoxicity. materials and ...

conclusions in the chinese han population that we studied, nafld patients who carry the tnf-α-238 ga polymorphism have an increased risk of developing cad. mechanisms underlying this potentially important association require further investigation. background cardiovascular events account for the main cause of death in patients with non-alcoholic fatty liver disease (nafld), and are largely infl...