Background: Pre-eclampsia is the most common critical condition during pregnancy. Plasma concentrations of tumor necrosis factor-alpha (TNF-α) and interleukin-1-beta (IL-1β) increase in pregnant women with pre-eclampsia, compared to normal pregnant women. Objective: To investigate the polymorphisms of IL-1β (C+3954T), TNF-α (G- 308A), and (G-238A) in preeclemptic women northeastern Iran. Me...

background and aims: plants as medicines have always played a vital role in human life. tumor necrosis factor alpha (tnf)-α is one of the macrophage-derived inflammatory cytokine with pleotropic effects in the inflammation process. some studies have been demonstrated that some of the echinops species have anti-inflammatory activity. in fact, echinops lasilepis is introduced as one of the native...

conclusions the results indicated that there was a positive association between susceptibility to chronic hbv infection and tnf-α polymorphism. in addition, hbv patients carrying -308 gg, -857 cc, and -863 aa genotypes with lower serum levels of tnf-α had an increased risk of infection. background the host genetic background regulates the natural history of chronic hepatitis b virus (hbv) infec...

Tumor necrosis factor-α is a cytokine with a wide range of effects on both lymphoid and non-lymphoid cells. In this study, we identified polymorphisms in major histocompatibility complex class III gene in the 4th exon and the 3' untranslated region of tumor necrosis factor-α to evaluate the immunogenetic diversity of Chinese south indigenous goat. Three single-nucleotide polymorphisms were iden...