Abstract Some specific chemotherapeutic drugs are able to enhance tumor immunogenicity and facilitate antitumor immunity by inducing immunogenic cell death (ICD). However, immunosuppression induced the adenosine pathway hampers this effect. In study, E-selectin-modified thermal-sensitive micelles designed co-deliver a drug (doxorubicin, DOX) an A2A receptor antagonist (SCH 58261), which simulta...

Antigen uptake receptors on dendritic cells (DCs) provide efficient entry for the initiation of antigen-specific adaptive immunity. Here we show that targeting of antigen to Fc receptors on DCs accomplishes combined activation of Th1 CD4 and CD8 effector responses in vivo, namely delayed-type hypersensitivity and tumor immunity. Tumor immunity specific for ovalbumin-expressing tumors was provid...

comas induced by aromatic hydrocarbons has been well established by Foley (2), Klein (8), Old (11), Prehn (12— 14), and others; but data on the antigenicity of spon taneously arising tumors in sparse. Morton (10) re ported briefly that the temporary growth of the first transplant generation of a spontaneous mammary adeno carcinoma in C3HJHEN mice conferred a significant degree of immunity to ...

Inflammation is necessary for immune defense against pathogens and a functional antitumor response, but chronic inflammation promotes tumor growth enables tumors to escape from immune-mediated destruction. Recently, we others demonstrated that deficiency of IL1β strongly favors immunity, multiple clinical trials involving antibody mediated blockade in cancers are underway. The mechanism, howeve...

Abstract Introduction and Objective: High-Intensity Focused Ultrasound (HIFU) is an FDA-approved procedure for the treatment of localized prostate cancer. HIFU destroys tumor tissue by noninvasively delivering ultrasonic energy, which rapidly heats targeted tissue. Prostate cancer has few tumor-infiltrating lymphocytes, are required antitumor immunity. The objective this study was to determine ...

Large Tumor Therapy In article number 2203227, Yanyu Huang, Liangping Luo, Zeyu Xiao, and co-workers report a localized radioimmunotherapeutic regimen by using X-ray irradiation metal-cyclic dinucleotide-containing nanomodulator for the treatment of large tumors. This combined paradigm amplifies STING signaling pathway elevating production 2′,3′-cGAMP activating both systematic anti-tumor immun...

Surface-bound IgE play a central role in antiparasite immunity; to exploit IgE-driven immune mechanisms in tumor prevention and control, monoclonal IgEs of irrelevant specificity were loaded through biotin-avidin bridging onto tumor cells, either by systemic administration to tumor-bearing mice or pre-loading of tumor cells before inoculation. Here we show that systemic administration of biotin...

BACKGROUND Radiofrequency ablation (RFA) is a minimally invasive tumor destruction technique and can provide the antigen source initiating tumor immunity. However, induced immune response is weak and requires additional immunotherapy for optimized RFA treatment against cancer. METHODS A murine orthotopic model of head and neck squamous cell carcinoma (HNSCC) was established to investigate the...

Abstract Melanoma cells activate Wnt/β-catenin signaling in the tumor microenvironment (TME) to promote progression and suppress dendritic cell-mediated anti-tumor immunity. However, role of β-catenin macrophages its effect on immunity is largely undefined. In this study, using XAV939, a tankyrase inhibitor encapsulated nanoparticles, we explored whether targeting can immunogenicity TME. Our da...