Background: Invasive ductal carcinoma is the most common type of breast cancer in Iran. Impaired immune responses occur frequently in cancer patients, but the mechanisms of the induced immune defects remain poorly understood. It is believed that infiltrated immune cells, especially macrophages, may provide help for tumor cell growth and metastasis.   Objective: To analyze the status of tumor as...

Whereas approximately half of metastatic melanoma patients benefit from combined immune checkpoint inhibition targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and Programmed cell death 1 (PD-1), for those who do not respond, further strategies treatment options need to be developed. Thus, focus is turning the use chimeric antigen receptor (CAR) T cells, a novel therapy that has ye...

To understand the role of various functional domains of simian virus 40 early tumor antigens, we have cloned and introduced into mouse cells portions of early simian virus 40 DNA. Two types of truncated large tumor antigen (33 and 12.3 kilodaltons), as well as small tumor antigen, were identified by immunoprecipitation. Both truncated large tumor antigens have been found to be overproduced with...

Abstract BACKGROUND Our previous studies has developed an adoptive cellular therapy (ACT) against high grade gliomas in both human and murine systems. ACT significantly improves survival models of CNS malignancies. have shown that efficacy is associated with the observed increase tumor-associated dendritic cells (DC) which arise from transferred hematopoietic stem (HSC). HSC-derived DCs play a ...

Background: The use of dendritic cells (DCs) as a cellular adjuvant provides a promis-ing approach in immunotherapy of cancer. It has been demonstrated that Listeria mono-cytogenes activated DCs pulsed ex vivo with tumor antigens trigger a systemic Th1-biased specific immune response and a single dose of this vaccine will cause a consider-able anti tumor immunity. Objective: The present study w...

Photomediated immunotherapy explored to combine the anti-cancer effect of phototherapy with immune enhancement ability immunotherapy, and shown great prospects for cancer treatment strategies. However, photomediated triggered antitumor immunity through release tumor antigens damage-associated molecular patterns from necrotic cells was not enough mighty improve therapeutic benefits due immunosup...