Rational combinatorial therapeutic strategies have proven beneficial for the management of cancer. Recent success of checkpoint blockade in highly immunogenic tumors has renewed interest in immunotherapy. Regulatory T (T reg) cells densely populate solid tumors, which may promote progression through suppressing anti-tumor immune responses. We investigated the role of T reg cells in murine mamma...

Teaser Figure: A volume rendering with the corresponding tumor map, a pseudo-cylindrical mapping of the tumor surface. Percutaneous radiofrequency (RF) ablation is a minimally invasive, image-guided therapy for the treatment of liver tumors. The assessment of the ablation area (coagulation) is performed to verify the treatment success as an essential part of the therapy. Traditionally, preand p...

OBJECTIVES To evaluate damage effect of High-intensity focused ultrasound on early stage endometrial cancer tissues and their vascularities. MATERIALS AND METHODS Rabbit endometrial cancer models were established via tumor blocks implantation for a prospective control study. Ultrasonic ablation efficacy was evaluated by pathologic and imaging changes. The target lesions of experimental rabbit...

Three definitive treatment options are available for patients with hepatic tumors: hepatic resection, tumor ablation, and hepatic transplantation. Ablative techniques--including radiofrequency ablation (RFA) and cryoablation--have greatly improved physicians' ability to definitively treat patients with primary and secondary hepatic tumors. Both RFA and cryoablation are safe and well-tolerated, ...

BACKGROUND Image-guided percutaneous thermal ablation is a commonly performed therapeutic procedure for various tumors. Thermal ablation is not frequently used in the pelvis as a result of anatomic concerns and the potential risk of nontarget tissue injury. TECHNIQUE Percutaneous thermal ablation is a minimally invasive procedure involving special probes inserted through the skin to the targe...