BACKGROUND AND PURPOSE It may be challenging to differentiate primary CNS lymphomas, especially primary CNS lymphomas with atypical MR features, from tumefactive demyelinating lesions by the use of conventional MR. This study aimed to investigate the usefulness of (1)H-MR spectroscopy for making this discrimination. MATERIALS AND METHODS Forty-four patients with primary CNS lymphomas and 21 w...

We report a case of pathologically confirmed tumefactive multiple sclerosis (MS) followed shortly thereafter by the diagnosis of an oligoastrocytoma. The complexity of diagnosis and management of concomitant presence of tumefactive MS and glial cell tumors is discussed.

Introduction: Ring-enhancing lesions is the most common abnormality faced in neuro-imaging. Imaging modalities commonly used to diagnose such are Computed Tomography (CT) and MRI. However, these considered challenging for radiologists. Diagnosing ring enhancing by conventional MRI challenging, especially when neoplastic, non-neoplastic infections be differentiated. Differentiation between tuber...

A 72-year-old man was admitted with left homonymous hemianopsia and hemiparesis. Magnetic resonance imaging revealed a heterogeneously enhanced lesion in the right parietal lobe. A brain biopsy showed acute demyelination without malignancy, which led to a diagnosis of tumefactive multiple sclerosis (MS). The patient received corticosteroid therapy and experienced clinical and radiological impro...

which typically develops between the ages of 20 and 40 years1. Neurosarcoidosis occurs in only 5-15% of adults with sarcoidosis, and is seldom reported in children2-5. Of the cases described in the literature, children were found more likely to present with seizures, and less commonly space-occupying lesions6. The tumefactive brain lesions are difficult to distinguish from the tumefactive demye...

Abstract IgG4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory condition with heterogeneous organ-specific manifestations. hypophysitis results from pituitary involvement and represents a rare neuro-ophthalmic complication of IgG4-RD, but the presentation as abscess exceptional. We report case 38-year-old otherwise healthy woman 3-year history relapsing sterile repeatedly treat...

We report a case of multiple sclerosis-associated fulminant tumefactive demyelinating lesion (TDL) with the special feature of delayed humoral immune response. Plasma exchange (PE) yielded significant benefit in two consecutive steroid-unresponsive relapses, while signs of an intrathecal B-cell response were only present 2 years later at the second relapse. Remission was achieved and sustained ...