BACKGROUND: Ten percent of all tuberculosis patients may develop skeletal involvement, and the spine is most common anatomical location. Tuberculous spondylitis further complicated by fast-acid bacilli resistance to usual chemotherapy regimen (multidrug-resistant/MDR) its complications. In this case series, we would like present three MDR tuberculous cases effectively treated with tailored regi...

STUDY DESIGN This is a retrospective series. PURPOSE We wanted to analyze the safety and effectiveness of using the newer generation metallic implants (pedicle screws and/or titanium mesh) for the treatment of tuberculous spondylitis. OVERVIEW OF THE LITERATURE: There have been various efforts to prevent the development of a kyphotic deformity after the treatment of tuberculous spondylitis, i...

Background: Tuberculous spondylitis or Pott’s disease results in characteristic deformity. In developed counties, Pott’s disease occurs primarily in older adult rather than children. In developing countries where the infection rate is high, it occurs mainly among children. Materials and Methods: We have reviewed the hospital records of pediatrics ward with diagnosis of tuberculosis between

The objective: to evaluate immediate and postponed results of surgical treatment tuberculosis (TB) in patients with TB/HIV co-infection. Subjects methods. 106 underwent surgery: 64 suffering from pulmonary (81.2% had resections, 18.8% – thoracoplasty), 36 tuberculous spondylitis (vertebral body resection combination anterior spondylodesis), 6 cerebral TB (removal lesions under neuronavigation)....

Etanercept is a tumor necrosis factor (TNF) inhibitor that has been used for the treatment of chronic inflammatory diseases including rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis. Because of its immunosuppressive activity, opportunistic infections have been noted in treated patients, most notably caused by Mycobacterium tuberculosis. Tuberculosis may present in an extrap...

Whole-genome analysis of Mycobacterium tuberculosis isolates collected in Russia (N = 71) from patients with tuberculous spondylitis supports a detailed characterization of pathogen strain distributions and drug resistance phenotype, plus distinguished occurrence and association of known resistance mutations. We identify known and novel genome determinants related to bacterial virulence, pathog...

OBJECTIVE To determine frequencies of different MRI patterns of tuberculous spondylitisin a public sector hospital in Karachi. METHODS This descriptive multidisciplinary case series study was done from October 25, 2011 to May 28, 2012 in Radiology Department and Department of Medicine in the Jinnah Postgraduate Medical Center Karachi. MRI scans (dorsal / lumbosacral spine) of the Patients pre...