BACKGROUND Deoxyribonuclease II (DNase II) is a well-known acidic endonuclease that catalyses the degradation of DNA into oligonucleotides. Only one or a few genes encoding DNase II have been observed in the genomes of many species. 125 DNase II-like protein family genes were predicted in the Trichinella spiralis (T. spiralis) genome; however, none have been confirmed. DNase II is a monomeric n...

in 1969 and 1976, 237 rodents and carnivores collected from the bandar abbas area south of iran was examined fro trichianella spiralis. 23% of foxes, 25% of stray dogs and all three captured golden jackals were found to be infected.

Due to its role in human Trichinellosis, there are increasing global requirements for reliable diagnostic method for Trichinella spiralis infection in pigs. Consequently, there is a need for selection of potent diagnostic antigen that could be successfully utilized in the diagnosis. Currently, two antigens (somatic and excretory-secretory antigens of T. spiralis larvae) were evaluated for the d...

The inhibitory effect of Ulva lactuca (Chlorophyta), Dilophus spiralis (Phaeophyta) and Jania rubens (Rhodophyta) marine algae species has been evaluated against 2 Grampositive bacterial (Streptococcus pyogenes and Micrococcus luteus); 2 Gram-negative bacterial (Shigella flexneri and Vibrio cholerae) and 2 fungal (Candida albicans and Aspergillus niger) isolates using aqueous and six organic ex...

Proteins secreted by Trichinella spiralis have a potential role in remodelling host skeletal muscle. However, whilst many parasite-secreted proteins have been identified, it has rarely been demonstrated that these are secreted into the nurse cell. Using an informatics-based analysis, we have searched the T. spiralis expressed sequence tag (EST) datasets for cDNAs encoding potential secreted pro...

Studies of nematode establishment in intestinal niches has been hindered by the lack of a readily manipulated in vitro assay. In this report, experiments are described wherein the larval stage of the parasitic nematode Trichinella spiralis was shown to invade epithelial cell monolayers in vitro. Larvae penetrated cells and migrated through them, leaving trails of dead cells in their wake. Cells...