نتایج جستجو برای: tspo

تعداد نتایج: 1222  

Introduction: It is well established that stress or the use of sulpiride, an antipsychotic, disrupts the reproductive system. Translocator protein (TSPO) in the mitochondrial membrane of steroidogenic tissues, such as gonads, is involved in the regulation of steroid hormone production by transporting cholesterol into the mitochondria. The present study aimed to investigate the effects of stress...

2014
Simona Daniele Sabrina Taliani Eleonora Da Pozzo Chiara Giacomelli Barbara Costa Maria Letizia Trincavelli Leonardo Rossi Valeria La Pietra Elisabetta Barresi Alfonso Carotenuto Antonio Limatola Anna Lamberti Luciana Marinelli Ettore Novellino Federico Da Settimo Claudia Martini

In the complex scenario of cancer, treatment with compounds targeting multiple cell pathways has been emerging. In Glioblastoma Multiforme (GBM), p53 and Translocator Protein (TSPO), both acting as apoptosis inducers, represent two attractive intracellular targets. On this basis, novel indolylglyoxylyldipeptides, rationally designed to activate TSPO and p53, were synthesized and biologically ch...

ژورنال: محیط زیست جانوری 2014

گرلین اثرات مهاری بر ترشح گنادوتروپین‌ ها اعمال می‌ کند. محصول ژن TSPO به‌ طور عمده در غشای خارجی میتوکندری یافت می‌ شود و یکی از پروتئین‌ های کلیدی در مسیر بیوسنتز استروئیدهای جنسی است. گرلین، کلسترول را به‌ داخل میتوکندری جهت سنتز هورمون‌ های جنسی انتقال می ‌دهد. تیمار موش‌ های صحرایی  ماده تازه متولد شده با تستوسترون پروپیونات (TP) الگوی ترشح گنادوتروپین ‌ها را در بلوغ تغییر می ‌دهد. دراین ت...

Journal: :The Journal of biological chemistry 1999
A A Yeliseev S Kaplan

A bacterial homolog of the mammalian mitochondrial benzodiazepine receptor, the tryptophan-rich sensory protein (TspO) has been previously demonstrated to negatively affect the transcriptional expression of several photosynthesis genes of Rhodobacter sphaeroides. To identify components of the signal transduction pathway from the outer membrane-localized TspO to the DNA-active transcription fact...

2015
Hee Kyoung Joo Yu Ran Lee Gun Kang Sunga Choi Cuk-Seong Kim Sungwoo Ryoo Jin Bong Park Byeong Hwa Jeon

Translocator protein 18 kDa (TSPO) is a mitochondrial outer membrane protein and is abundantly expressed in a variety of organ and tissues. To date, the functional role of TSPO on vascular endothelial cell activation has yet to be fully elucidated. In the present study, the phorbol 12-myristate 13-acetate (PMA, 250 nM), an activator of protein kinase C (PKC), was used to induce vascular endothe...

2017
Nasra Yasin Leo Veenman Sukhdev Singh Maya Azrad Julia Bode Alex Vainshtein Beatriz Caballero Ilan Marek Moshe Gavish

It is known that knockdown of the mitochondrial 18 kDa translocator protein (TSPO) as well as TSPO ligands modulate various functions, including functions related to cancer. To study the ability of TSPO to regulate gene expression regarding such functions, we applied microarray analysis of gene expression to U118MG glioblastoma cells. Within 15 min, the classical TSPO ligand PK 11195 induced ch...

Journal: :Brain, Behavior, and Immunity 2016
Eva Kosek Sofia Martinsen Björn Gerdle Kaisa Mannerkorpi Monika Löfgren Indre Bileviciute-Ljungar Peter Fransson Martin Schalling Martin Ingvar Malin Ernberg Karin B. Jensen

The translocator protein (TSPO) is upregulated during glia activation in chronic pain patients. TSPO constitutes the rate-limiting step in neurosteroid synthesis, thus modulating synaptic transmission. Related serotonergic mechanisms influence if pro- or anti-nociceptive neurosteroids are produced. This study investigated the effects of a functional genetic polymorphism regulating the binding a...

Journal: :Brain, behavior, and immunity 2013
Jonas Hannestad Nicole DellaGioia Jean-Dominique Gallezot Keunpoong Lim Nabeel Nabulsi Irina Esterlis Brian Pittman Jae-Yun Lee Kevin C O'Connor Daniel Pelletier Richard E Carson

Depression is associated with systemic inflammation. In animals, systemic inflammation can induce neuroinflammation and activation of microglia; however, postmortem studies have not convincingly shown that there is neuroinflammation in depression. The purpose of this study was to use positron emission tomography (PET) with [¹¹C]PBR28, which binds to the neuroinflammation marker translocator pro...

2015
Jason R. Buck Eliot T. McKinley Allie Fu Ty W. Abel Reid C. Thompson Lola Chambless Jennifer M. Watchmaker James P. Harty Michael K. Cooper H. Charles Manning Karl Herholz

Current positron emission tomography (PET) imaging biomarkers for detection of infiltrating gliomas are limited. Translocator protein (TSPO) is a novel and promising biomarker for glioma PET imaging. To validate TSPO as a potential target for molecular imaging of glioma, TSPO expression was assayed in a tumor microarray containing 37 high-grade (III, IV) gliomas. TSPO staining was detected in a...

2012
Alex Sik Chung Ching Bertrand Kuhnast Annelaure Damont Dirk Roeda Bertrand Tavitian Frédéric Dollé

Neuroinflammation is a process characterised by drastic changes in microglial morphology and by marked upregulation of the 18-kDa translocator protein (TSPO) on the mitochondria. The continual increase in incidence of neuroinflammation and neurodegenerative diseases poses a major health issue in many countries, requiring more innovative diagnostic and monitoring tools. TSPO expression may const...

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