The fuzzy inference system proposed by Takagi, Sugeno, and Kang, known as the TSK model in fuzzy system literature, provides a powerful tool for modeling complex nonlinear systems. Unlike conventional modeling where a single model is used to describe the global behavior of a system, TSK modeling is essentially a multimodel approach in which simple submodels (typically linear models) are combine...

The Tight Skin (TSK) mouse is a mutant strain that displays connective tissue abnormalities characterized by excessive accumulation of collagen in skin, subcutaneous tissues, and some internal organs such as the heart. Increased collagen biosynthesis by skin organ cultures from affected mice has been previously demonstrated, but the mechanisms responsible have not been identified. In order to e...

PURPOSE Individuals with cardiac problems avoid physical activity and exercise because they expect to feel shortness of breath, dizziness, or chest pain. Assessing kinesiophobia related to heart problems is important in terms of cardiac rehabilitation. The Tampa Scale of Kinesiophobia Swedish Version for the Heart (TSK-SV Heart) is reliable and has been validated for cardiac diseases in the Swe...

The TSK mouse, a model of fibrosis, displays exaggerated connective tissue accumulation in skin and visceral organs including the heart. To study the mechanisms of myocardial fibrosis in TSK mice, we established several strains of TSK mice myocardial fibroblasts in culture and examined the regulation of collagen gene expression in these cells. These strains displayed increased collagen gene exp...

OBJECTIVES To create reference values for the general Finnish population using the Tampa Scale of Kinesiophobia (TSK-FIN), to study gender differences in the TSK-FIN, to assess the internal consistency of the TSK-FIN, to estimate the prevalence of high levels of kinesiophobia in Finnish men and women, and to examine the association between kinesiophobia and leisure-time physical activity and th...

Introduction: After anterior cruciate ligament (ACL) injury, potential copers (PCs) and non-copers (NCs) are differentiated based on functional ability and knee stability. Due to frequent episodes of the knee giving way, rehabilitation specialists recommend NCs undergo ACL reconstruction (ACLR) prior to the resumption of sport activities. Some PCs opt to have non-operative management while othe...

An interval type-2 TSK fuzzy logic system can be obtained by considering the membership functions of its existed type-1 counterpart as primary membership functions and assigning uncertainty to cluster centers, standard deviation of Gaussian membership functions and consequence parameters. In many cases it has been difficult to determine the spread percentages for these parameters to obtain an o...

OBJECTIVE Systemic sclerosis (SSc) is an autoimmune disease clinically manifesting as progressive fibrosis of the skin and internal organs. Cadherin-11 (CDH11) expression is increased in fibrotic skin and lung tissue. Targeting CDH11 may be an effective approach to treating fibrosis. We hypothesize that targeting CDH11 will decrease fibrosis in the tight skin-1 (Tsk-1) mouse model. METHODS CD...

Three classes of signaling molecule, VG1, WNT and BMP, play crucial roles in axis formation in the chick embryo. Although VG1 and WNT signals have a pivotal function in inducing the primitive streak and Hensen's node in the embryo midline, their action is complemented by that of BMP antagonists that protect the prospective axial tissue from the inhibitory influence of BMPs secreted from the per...