OBJECTIVE In Iran thyroid-stimulating hormone (TSH) based neonatal screening program is included in health care services from 2005 for detection of patients with primary congenital hypothyroidism (CH). This study was performed for a critical evaluation of the screening program primary congenital hypothyroidism in Fars province, Iran. METHODS From November 2006 to September 2007, TSH serum con...

Lower cutoff levels in screening programs have led to an increase in the proportion of detected cases of transient hypothyroidism, leading to an increase in the overall prevalence of primary congenital hypothyroidism (CH) in several countries. We have performed a retrospective evaluation on the data from 251,008 (96.72%) neonates screened for thyroid-stimulating hormone (TSH) level in dried blo...

Objective: Pediatrician is the first contact in the Pathway to Care in children with Mental retardation (MR). Following the recent advancements in the area of molecular genetics, understanding of specific conditions of MR or Developmental Delay (DD) is expanding. Hypothyroidism is a treatable metabolic/endocrinological cause of MR. The aim of this study was to determine the prevalence of hypoth...

OBJECTIVE The aims of this study were to demonstrate ventricular function changes in patients with congenital hypothyroidism and to investigate whether there is an association between any such changes and thyroid-stimulating hormone (TSH) levels using M-mode and Doppler electrocardiography (ECG) and tissue Doppler imaging (TDI). METHODS Twenty-seven patients 5-30 days of age with congenital h...

Background & Aims: Congenital hypothyroidism (CH) is one of the most common preventable causes of mental retardation throughout the world. The aim of this study was to investigate the prevalence of CH among newborns of East Azerbaijan province in 2009-2010. Methods: This descriptive analytic study was performed by using census cross- sectional method on 62459 neonates in East Azerbaijan pro...

Thyrotropin (TSH) stimulates hormonogenesis using the iodate substrate and tyrosine amino acid. After various enzymatic reactions, thyroxine (T4) and triiodothyronine (T3) are released. Part of the hormone freely circulates in serum as free T3 (FT3) and free T4 (FT4). TSH is released after feedback. A study was undertaken to determine cut-off levels of FT4 to verify hypothalamic and pitutitary ...

Previous studies of congenital hypothyroidism have suggested an increasing incidence and seasonal variation in incidence, which may suggest nongenetic factors involved in aetiology. This study describes the incidence of elevated thyroid stimulating hormone (TSH) values in newborns, a surrogate for congenital hypothyroidism, measured as part of the screening programme for congenital hypothyroidi...

Congenital central hypothyroidism (CCH) is a rare condition occurring in 1 : 20000 to 1 : 50000 newborns. As TSH plasma levels are low, CCH is usually not detected by TSH-based neonatal screening for hypothyroidism, and, as a result, diagnosis is often delayed putting affected children at risk for developmental delay and growth failure. We report on a girl with isolated central hypothyroidism d...