BACKGROUND Flunarizine dihydrochloride (FLN) is used in the prophylactic treatment of migraine, vertigo, occlusive peripheral vascular disease and epilepsy. Cyclodextrins (CDs) are chiral, truncated cone shaped macrocycles known for their inner hydrophobic and outer hydrophilic site. They form complexes with hydrophobic drug molecules and enhance the solubility and bioavailability of such compo...

Using an asymptotic integration method, this paper investigates the axisymmetric problem of elasticity theory for inhomogeneous transversal-isotropic truncated cone small thickness. It is believed that moduli are arbitrary continuous functions opening angle. assumed lateral part free stresses, and boundary conditions set at ends cone, leaving it in equilibrium. Homogeneous solutions have been c...

The nonselective cation channel transient receptor potential canonical (TRPC)5 is found predominantly in the brain and has been proposed to regulate neuronal processes and growth cones. Here, we demonstrate that semaphorin 3A-mediated growth cone collapse is reduced in hippocampal neurons from TRPC5 null mice. This reduction is reproduced by inhibition of the calcium-sensitive protease calpain ...

The algorithm of Feldkamp, Davis, and Kress [J. Opt. Soc. Am. A 1, 612-619 (1984)] is a widely used filtered-backprojection algorithm for three-dimensional image reconstruction from cone-beam (CB) projections measured with a circular orbit of the x-ray source. A well-known property of this approximate algorithm is that the integral of the reconstructed image along any axial line orthogonal to t...

Here we propose a cone-beam composite-circling mode to solve the quasi-short object problem, which is to reconstruct a short portion of a long object from longitudinally truncated cone-beam data involving the short object. In contrast to the saddle curve cone-beam scanning, the proposed scanning mode requires that the X-ray focal spot undergoes a circular motion in a plane facing the short obje...

The present work studies an axisymmetric rotating truncated cone made of functionally graded (FG) porous materials reinforced by graphene platelets (GPLs) under a thermal loading. problem is tackled theoretically based on classical linear thermoelasticity approach. consists layered material with uniform or non-uniform dispersion GPLs in metal matrix open-cell internal pores, whose effective pro...

The uncertainty management problem is one of the key issues associated with moving objects (MOs). Minimizing the uncertainty region size can increase both query accuracy and system performance. In this paper, we propose an uncertainty model called the Truncated Tornado model as a significant advance in minimizing uncertainty region sizes. The Truncated Tornado model removes uncertainty region s...

Single point incremental forming (SPIF) process has proven benefits in terms of formability, flexibility, and low cost as compared to conventional sheet forming, although it some issues such dimensional accuracy quality surface finish for materials. The SPIF is considered a potential method producing customised medical parts craniofacial implants using titanium sheet. This investigation aims an...

Alternative splicing of nucleoredoxin-like 1 (Nxnl1) results in 2 isoforms of the rod-derived cone viability factor. The truncated form (RdCVF) is a thioredoxin-like protein secreted by rods that promotes cone survival, while the full-length isoform (RdCVFL), which contains a thioredoxin fold, is involved in oxidative signaling and protection against hyperoxia. Here, we evaluated the effects of...