We reported a 71 years old woman, with history of rest and postural tremor, bradykinesia and memory problems. In her dynamic MRI, a contrastenhanced tumor in the cerebellopontine (CP) angle was found which was compatible with a meningioma. 99mTc-TRODAT SPECT showed decreased activity in the left putamen, indicating idiopathic Parkinson disease. There was also a focus of increased activity on th...

An 84-year-old woman underwent a dopamine transporter (DAT) study to investigate a non-levodopa-responsive parkinsonism. A SPECT brain scan was conducted four hours after intravenous administration of 1110 MBq (megabecquerels) equivalent to 30 mCi (millicuries) of 99mTc–TRODAT-1. The study revealed a significant uptake deficit of radiopharmaceuticals in the striatum. The semi-quantitative analy...

Corticobasal degeneration (CBD) is a rare neurodegenerative disorder characterized by distinctive clinical manifestations including asymmetric akinetic-rigid syndrome and higher cortical dysfunctions. We characterized the clinical, electrophysiological and imaging presentations in four patients with CBD. All patients exhibited unilateral hand dystonia, rigidity and apraxia, but showed no signif...

UNLABELLED The clinical diagnosis of Parkinson's disease (PD) is susceptible to misdiagnosis, especially in the earlier stages of the disease. Recently, in vivo imaging techniques assessing the presynaptic dopamine transporter (DAT) have emerged as a useful tool in PD diagnosis, improving its accuracy. OBJECTIVE It was to illustrate the clinical usefulness of a brain single-photon emission co...

OBJECTIVE To describe clinical and neuroimaging (SPECT) characteristics of Brazilian patients with Parkinson's disease (PD) and mutations in PARK2 or PARK8 genes. METHOD A total of 119 patients meeting clinical criteria for PD were evaluated. RESULTS Of all patients studied, 13 had mutations in either PARK2 (n=9) or PARK8 genes (n=4). No statistically significant differences in clinical cha...