An 84-year-old woman underwent a dopamine transporter (DAT) study to investigate a non-levodopa-responsive parkinsonism. A SPECT brain scan was conducted four hours after intravenous administration of 1110 MBq (megabecquerels) equivalent to 30 mCi (millicuries) of 99mTc–TRODAT-1. The study revealed a significant uptake deficit of radiopharmaceuticals in the striatum. The semi-quantitative analy...

Parkinson’s disease (PD) is one of the most common neurological disorder diseases which takes place when brain cells gradually die. PD considered a challengeable because similarities between and other disorders. For this reason, there are several ways to diagnose PD. Nuclear medicine can be solution distinguish some disorders The aim review understand differences three radiopharmaceuticals used...

OBJECTIVE The biological properties of a new neutral myocardial imaging agent 99mTcN(NOEt)2 were evaluated. METHODS Blood clearance in rabbits, biodistribution in rats, and initial myocardial imaging in dogs were performed. RESULTS Radiochemical purity of 99mTcN(NOEt)2 was more than 90% and stable for 6 h at room temperature. Blood disappearance was analyzed with a biexponential model and T...

Hydrazinonicotinamide (HYNIC) is an established bifunctional complexing agent for technetium-99m ((99m)Tc) but the structure of the technetium coordination sphere remains uncertain. To gain further insight into this, we have prepared conjugates of HYNIC and hydrazinobenzoic acid (HYBA) with a model peptide, and radiolabelled them with (99m)Tc using three well-established co-ligand systems: EDDA...

J Nucl Med. Andrew Taylor, Jr., Frederick Akiya and Martin C. Gregory Preclude Recoverable Function Failure to Visualize Acutely Injured Kidneys with Technetium-99m DMSA Does Not http://jnm.snmjournals.org/content/27/3/377 This article and updated information are available at: http://jnm.snmjournals.org/site/subscriptions/online.xhtml Information about subscriptions to JNM can be found at: http...

Introduction Cognitive impairments, the main determinants of functional outcomes in schizophrenia, had limited treatment responses and need a better understanding mechanisms. Dysfunctions dopamine system N-methyl-D-aspartate receptor (NMDAR), primary pathophysiologies may impair cognition. Objectives This study explored effects interactions striatal transporter (DAT) plasma NMDAR-related amino ...