نتایج جستجو برای: trkb

تعداد نتایج: 2355  

Journal: :Molecular vision 2001
B Rohrer

PURPOSE To strengthen our understanding about the role of trkB in rod development by correlating functional and biochemical retinal phenotypes with levels of trkB expression in two independently created trkB transgenic lines. METHODS Juvenile mice that carried two hypomorphic trkB alleles (trkBfbz/fbz) expressing roughly 25% of normal trkB, and their heterozygous (trkB+/fbz) and wild type (WT...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Rui P Galvão José Manuel Garcia-Verdugo Arturo Alvarez-Buylla

In rodents, the adult subventricular zone (SVZ) generates neuroblasts which migrate to the olfactory bulb (OB) and differentiate into interneurons. Recent work suggests that the neurotrophin Brain-Derived Neurotrophic Factor (BDNF) can enhance adult SVZ neurogenesis, but the mechanism by which it acts is unknown. Here, we analyzed the role of BDNF and its receptor TrkB in adult SVZ neurogenesis...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Yang Zhong Huang James O McNamara

Reactive oxygen species (ROS) have diverse biological consequences in the mammalian CNS, but the molecular targets mediating these pleiotropic effects are incompletely understood. Like ROS, the neurotrophin receptor, TrkB receptor tyrosine kinase, has diverse effects in the developing and mature mammalian brain. Our discovery that zinc can transactivate TrkB, together with the finding that ROS ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Géraldine Liot Diana Zala Patrick Pla Guillaume Mottet Matthieu Piel Frédéric Saudou

Huntingtin (HTT), the protein mutated in Huntington's disease (HD), controls transport of the neurotrophin, brain-derived neurotrophic factor (BDNF), within corticostriatal neurons. Transport and delivery of BDNF to the striatum are reduced in disease, which contributes to striatal neuron degeneration. BDNF released by cortical neurons activates TrkB receptors at striatal dendrites to promote s...

Journal: :Muscle & nerve 2012
Carlos B Mantilla Leonid G Ermilov

Neurotrophin signaling at the neuromuscular junction modulates cholinergic transmission and enhances neuromuscular transmission via the tropomyosin-related kinase receptor subtype B (TrkB).A novel flavonoid, 7,8-dihydroxyflavone (7,8-DHF), selectively activates TrkB receptors. Using TrkB(F616A) mice that are susceptible to specific inhibition of TrkB activity by 1NMPP1, we show that neuromuscul...

Journal: :Frontiers in Synaptic Neuroscience 2021

Perineuronal nets (PNNs) have an important physiological role in the retention of learning by restricting cognitive flexibility. Their deposition peaks after developmental periods intensive learning, usually late childhood, and they help long-term preservation newly acquired skills information. Modulation PNN function various techniques enhances plasticity regulates memories, which may be benef...

Journal: :The Journal of biological chemistry 2003
Tami J Kingsbury Peter D Murray Linda L Bambrick Bruce K Krueger

The neurotrophin brain-derived neurotrophic factor (BDNF), via activation of its receptor, tyrosine receptor kinase B (trkB), regulates a wide variety of cellular processes in the nervous system, including neuron survival and synaptic plasticity. Although the expression of BDNF is known to be Ca2+-dependent, the regulation of trkB expression has not been extensively studied. Here we report that...

2016
Andres Stucky Kalindi P. Bakshi Eitan Friedman Hoau-Yan Wang

Prenatal cocaine exposure causes profound changes in neurobehavior as well as synaptic function and structure with compromised glutamatergic transmission. Since synaptic health and glutamatergic activity are tightly regulated by brain-derived neurotrophic factor (BDNF) signaling through its cognate tyrosine receptor kinase B (TrkB), we hypothesized that prenatal cocaine exposure alters BDNF-Trk...

Journal: :Molecular pharmacology 2012
Yang Zhong Huang Frank J Hernandez Bin Gu Katie R Stockdale Kishore Nanapaneni Todd E Scheetz Mark A Behlke Andrew S Peek Thomas Bair Paloma H Giangrande James O McNamara

Many cell surface signaling receptors, such as the neurotrophin receptor, TrkB, have emerged as potential therapeutic targets for diverse diseases. Reduced activation of TrkB in particular is thought to contribute to neurodegenerative diseases. Unfortunately, development of therapeutic reagents that selectively activate particular cell surface receptors such as TrkB has proven challenging. Like...

Journal: :Neuron 1997
Hyejin Kang Andy A Welcher David Shelton Erin M Schuman

We examined the role of TrkB ligands in hippocampal long-term potentiation (LTP) using function-blocking TrkB antiserum (Ab) and Trk-IgG fusion proteins. Incubation of hippocampal slices with TrkB Ab had no effect on basal synaptic transmission, short-term plasticity, or LTP induced by several trains of tetanic stimulation. The TrkB Ab-treated slices, however, showed significant deficits in LTP...

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