Using carboranes as counterions, fluorinated benzyl-type carbocations such as (p-FC(6)H(4))(2)CF(+), (p-FC(6)H(4))(CH(3))CF(+) and fluorinated trityl ions are readily isolated for X-ray and IR structural characterization.

Solvolysis of trichloroacetate esters of 2-methoxy-1,2-dihydro-1-naphthols shows a remarkably large difference in rates between the cis and trans isomers, k(cis)/k(trans) = 1800 in aqueous acetonitrile. This mirrors the behaviour of the acid-catalysed dehydration of cis- and trans-naphthalene-1,2-dihydrodiols to form 2-naphthol, for which k(cis)/k(trans) = 440, but contrasts with that for solvo...

A novel proton acceptor coupling reagent shows superiority to those described previously. The oxygen in the carbocation moiety confers more solubility to the reagent. Furthermore, it enhances coupling yields and decreases racemization, allowing the use of 1 equiv of base.

Understanding the interactions of trityl radicals with proteins is required to expand their biomedical applications. In this work, we demonstrate that the Finland trityl radical CT-03 binds to bovine serum albumin (BSA) in aqueous solution. Upon binding with BSA, CT-03 exhibits a much broader electron paramagnetic resonance (EPR) signal and this line broadening can be reversed by proteolysis of...

Human Eg5, a member of the kinesin superfamily, plays a key role in mitosis, as it is required for the formation of a bipolar spindle. We describe here the first in vitro microtubule-activated ATPase-based assay for the identification of small-molecule inhibitors of Eg5. We screened preselected libraries obtained from the National Cancer Institute and identified S-trityl-L-cysteine as the most ...

Degenerate 1,2-shift of methylethynyl group in long-lived 9,10-dimethyl-9-methylethynyl-phenanthrenium ion has been detected by NMR. This is the first example of ethynyl migration in a long-lived carbocation.

We report that tetrathiatriarylmethyl (trityl) EPR probes are chiral molecules at room temperature, the two stereoisomers that differ in their helicity being configurationally stable enough to be separated and stored independently.

Novel dendritic trityl radicals (DTR1 and DTR2) with a TAM radical core, PAMAM branching and carboxylate exterior surface exhibit high stability towards oxidoreductants as evidenced by their electrochemical and EPR properties, offering potential application as dual oxygen and pH probe.

Treatment of dialkylbenzylsilane (1) with trityl tetrakis(pentafluorophenyl)borate (TPFPB) in the presence of terminal or internal alkynes (3) and 2,6-di-tert-butyl-4-methylpyridine gave the corresponding 1,2-dihydro-2-silanaphthalene derivatives (4) in 34-82% yields.

A new reaction of oxidative substitution of aromatic carboxyl groups on stable trityl radical derivatives (TAMs) by various nucleophiles is described; it leads to a wide variety of new persistent and diversely substituted TAM radicals.