Ditercalinium (NSC 335153), a bifunctional intercalating molecule with antitumor activity, is found to express its toxicity through a mech anism of action completely different from that of other monointercalating agents. Electron microscopic observation of ditercalinium-treated cells shows a drastic alteration of mitochondria! structure. Cells deficient in mito chondria! respiration (GSK3 cells...

The mechanism of action of aunomomycin, a new tumor inhibitory antibiotic, was studied in a growing culture of mouse lymphoblastoma L51 78Y cells and with isolated viral DNA. Auromomycin prevented growth of L5i 78Y cells completely and irreversibly at antibiotic concentrations higher than 0.03 pg/mI. DNA synthesis was preferentially inhibited by the anti biotic, whereas RNA and protein synthese...

We present a practical and e cient garbage collection mechanism for large scale distributed systems The mechanism collects all garbage including distributed cyclic garbage without global synchronization or back ward links The primary method used for local and remote garbage collection is timeouts each object has a time to live and clients which have a link to an ob ject must refresh the target ...

Since nitric oxide (NO) was first described as endothelium derived relaxing factor (EDRF),I there has been compelling evidence that NO is involved in very many biological processes.2-9 It has at least four roles in the lungs.3 These are as a pulmonary vasodilator, bronchodilator, non-adrenergic non-cholinergic transmitter, and inflammatory mediator. There are three types of NO synthase, the enz...

According to one brain-theoretical view, high~!:.brainful1ctionsarebased on processing_!!l1j.ts called cell as~~mbJiys. <::ell assemblies are large groups of corticalpyramidal neurons with strong and reclproc-al internal connections. C~lla,ssemblies develop in a randomIy-connected neuronal network when sets of neurons are frequently attive-simillfaneolisly so that their connectionsEstrengthen (...

One of the widest ranging abiotic stresses in world agriculture arises from low zinc (Zn) availability in calcareous soils, particularly in cereals. Cereal species greatly differ in their zinc effici ency (ZE), defined in this article as the ability of a plant to grow and yield well under Zn deficiency. ZE has been attributed mainly to the effi ciency of acquisition of Zn under conditions of lo...

8 In constructing improved models of human behavior, both experimental and behavioral econo9 mists have increasingly turned to evolutionary theory for insights into human psychology and 10 preferences. Unfortunately, the existing genetic evolutionary approaches can explain neither the 11 degree of prosociality (altruism and altruistic punishment) observed in humans, nor the patterns of 12 varia...

Differential privacy is a robust privacy standard that hasbeen successfully applied to a range of data analysis tasks.But despite much recent work, optimal strategies for answer-ing a collection of related queries are not known.We propose the matrix mechanism, a new algorithm foranswering a workload of predicate counting queries. Givena workload, the mechanism requests a...

The heats o f transport o f several substitutional impurities (such as Sb, Sn, In, Ag, N i and Co) in copper and silver are discussed in terms o f atom ic quantities. They are considered as consisting of essentially two parts. The first one, the so-called intrinsic heat o f transport, can be derived from the electrostatic potential generated by the im purity at the site o f a normal lattice ato...

In semantic and object oriented data models each class has one or more typing properties that associate it to other classes and carry type information about all instances of the class We introduce a new kind of property that we call instance typing property An instance typing property associates an instance of a class to another class and carries type information about that particular instance ...