نتایج جستجو برای: trim

تعداد نتایج: 2247  

2016
Wenchun Fan Mengge Wu Suhong Qian Yun Zhou Huanchun Chen Xiangmin Li Ping Qian

The members of tripartite-motif containing (TRIM) protein participate in various cellular processes and play an important role in host antiviral function. TRIM proteins exert their antiviral activity either directly by degrading viral proteins through their E3 ligase activity, or indirectly by promoting host innate immunity. This study demonstrated for the first time that TRIM52 is a novel anti...

2016
Carlos Oliveira Matthew Charlton Rakesh Mishra

It is well established that inlet flow characteristics may affect the performance of fluid handling systems considerably. This work focuses on the local flow analysis of a severe service control valve with a continuous resistance trim (CRT) operating under multiphase flow conditions and the effect of the inlet flow characteristics on the dispersed phase distribution within the trim and the valv...

Journal: :Nature Reviews Molecular Cell Biology 2003

2014
Luigi Cormio Clarbruno Vedruccio Giorgio Leucci Paolo Massenio Giuseppe Di Fino Vincenzo Cavaliere Giuseppe Carrieri

Objectives. Normal and neoplastic human tissues have different electromagnetic properties. This study aimed to determine the diagnostic accuracy of noninvasive electromagnetic detection of bladder cancer (BC) by the tissue-resonance interaction method (TRIM-prob). Patients and Methods. Consecutive patients were referred for cystoscopy because of (i) microscopic or gross hematuria and/or irritat...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Jacint G Sanchez Katarzyna Okreglicka Viswanathan Chandrasekaran Jordan M Welker Wesley I Sundquist Owen Pornillos

Tripartite motif (TRIM) proteins make up a large family of coiled-coil-containing RING E3 ligases that function in many cellular processes, particularly innate antiviral response pathways. Both dimerization and higher-order assembly are important elements of TRIM protein function, but the atomic details of TRIM tertiary and quaternary structure have not been fully understood. Here, we present c...

Journal: :Journal of Biochemistry 2017

2013
Inga Loedige Dimos Gaidatzis Ragna Sack Gunter Meister Witold Filipowicz

TRIM-NHL proteins are conserved regulators of development and differentiation but their molecular function has remained largely elusive. Here, we report an as yet unrecognized activity for the mammalian TRIM-NHL protein TRIM71 as a repressor of mRNAs. We show that TRIM71 is associated with mRNAs and that it promotes translational repression and mRNA decay. We have identified Rbl1 and Rbl2, two ...

Journal: :Revista espanola de anestesiologia y reanimacion 2015
J F Velásquez J P Cata

Approximately half of cancer patients scheduled for major surgery are anemic. Also, a significant number of patients will present to the operating room with low platelet counts and coagulopathic disorders. Unfortunately, administration of red blood cells, platelets concentrates and fresh-frozen plasma is associated with unwanted adverse effects including fever, hemolytic reactions and transfusi...

2002
V. Gavrilets B. Mettler

In this paper we describe the control logic that enabled a small-scale unmanned helicopter to execute a completely automatic aerobatic maneuver. The logic consists of steady-state trim trajectory controllers, used prior to, and upon the exit from the maneuver; and a maneuver logic inspired by human pilot strategies. Extensive flight tests with this control logic demonstrated smooth entry into t...

2011
Kyudong Han Dianne I. Lou Sara L. Sawyer

Tripartite Motif (TRIM) ubiquitin ligases act in the innate immune response against viruses. One of the best characterized members of this family, TRIM5α, serves as a potent retroviral restriction factor with activity against HIV. Here, we characterize what are likely to be the youngest TRIM genes in the human genome. For instance, we have identified 11 TRIM genes that are specific to humans an...

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