background: trichomoniasis is an extremely common sexually transmitted infection (sti) world­wide and is associated with important public health problems, including amplification of hiv transmission. this disease is in forms of symptomatic and asymptomatic in women and may de­pend on host as well as parasite variables. most of the studies reported from females are based on examination of vagina...

background: as for human trichomoniasis the host-parasite relationship is very complex, and the broad ranges of clinical symptoms are unlikely be attributable to a single pathogenic mechanism. specific random amplified polymorphic dna (rapd) markers of 490 bp, 720 bp and 460 bp using the primers tv-5, opa-6 and opa-11, respectively, were reported. this was the first description of possible ge­n...

trichomoniasis is one of the most common urinary-genital tract disease. the causal agent of trichomoniasis is flagellate protozoan called trichomonas vaginalis. metronidazole and tinidazole are the drug of choice for treatment. carcinogenic and embryo-teratogenic effects of the mentioned drugs and resistance to metronidazole has been reported. according to cytotoxic effects of medicinal herbs i...

Trichomonas vaginalis infection is estimated to be the most widely prevalent nonviral sexually transmitted infection in the world. Wet-mount microscopy is the most common diagnostic method, although it is less sensitive than culture. The OSOM Trichomonas Rapid Test (Genzyme Diagnostics, Cambridge, Mass.) (referred to here as OSOM) is a new point-of-care diagnostic assay for T. vaginalis that us...

Broth culture of Trichomonas vaginalis is considered the "gold standard" for the diagnosis of trichomoniasis. Two studies were carried out to evaluate modified Columbia agar (MCA) for the isolation of T. vaginalis from clinical samples. Study I compared isolation on MCA to that on liquid medium with 889 vaginal samples. Out of 63 samples positive for T. vaginalis (7.1% of total), MCA identified...

Multifarious transcription of the adhesion protein ap65-1 gene in the human pathogen, Trichomonas vaginalis, is critically regulated by the coordination of two similar but opposite oriented DNA regulatory regions, MRE-1/MRE-2r and MRE-2f, both of which are binding sites for multiple Myb-like proteins. In the present study, MRE-1/MRE-2r was demonstrated to be composed of multiple overlapping pro...

Despite the declining rate of sexually transmitted diseases in developed countries, trichomoniasis is still one of the most common venereal infections. While diagnosis of this condition is commonly based on the microscopic wet-mount method, culture remains the most accurate single procedure for detecting the presence of Trichomonas vaginalis in clinical samples. In the present study, the effica...

Although many investigations into Trichomonas vaginalis Donne 1875 and vaginal trichomoniasis have been made since the organism was recognized again as a pathological entity by Hohne in 1916, problems on its pathogenicity, epidemiology and therapeutics are still left in confusion. One of the main reasons of this confusion appears that the bacteria free cultivation of this organism has not been ...

Trichomonas vaginalis was first described by Donne (1836), who observed the organism in purulent secretions in both women and men, and stated that it was not present in normal vaginal secretions. T. vaginalis was successfully cultured in vitro by Lynch (1915), and there have since been a number of publications containing descriptions of the morphological, epidemiological, and pathological aspec...